Evidence map›Paper›PMID 37008567›Full record

ArticleOpen forum infectious diseases2023

Breakthrough Invasive Fungal Infection After Coadministration of Venetoclax and Voriconazole.

Victoria G Hall, Kenny Tang, Deepali Kumar, Coleman Rotstein, Signy Chow, Steven M Chan, Shahid Husain, Seyed M Hosseini-Moghaddam

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Victoria G HallTransplant-Oncology Infectious Diseases, University Health Network, Toronto, Ontario, Canada.
Kenny TangDepartment of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Deepali KumarTransplant-Oncology Infectious Diseases, University Health Network, Toronto, Ontario, Canada.
Coleman RotsteinTransplant-Oncology Infectious Diseases, University Health Network, Toronto, Ontario, Canada.
Signy ChowDepartment of Hematology, Sunnybrook Health Sciences, Toronto, Ontario, Canada.
Steven M ChanDepartment of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Shahid HusainTransplant-Oncology Infectious Diseases, University Health Network, Toronto, Ontario, Canada.
Seyed M Hosseini-MoghaddamTransplant-Oncology Infectious Diseases, University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-7979-2458
University Health Network · CAPrincess Margaret Cancer Centre · CASunnybrook Health Science Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Venetoclax requires a 75% dose reduction when coadministered with voriconazole. In a 10-year historical cohort of treatment with venetoclax, we did not observe a worse hematologic outcome in patients who received voriconazole prophylaxis versus those who did not. Subtherapeutic voriconazole levels and a triazole exposure history may contribute to breakthrough invasive fungal infection.

Indexed as

breakthroughinvasive fungal infectionvenetoclaxvoriconazole

Identifiers

PMID37008567
PMCPMC10064263
OpenAlexW4327612722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.