ReviewFrontiers in veterinary science2023
Advances in eggshell membrane separation and solubilization technologies.
Review in Frontiers in veterinary science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Eggshell membrane-based biomaterials for tissue regeneration: a systematic review of preclinical evidence.Frontiers in bioengineering and biotechnology · 2026Pooled it
- Efficacy of Eggshell Membrane in Knee Osteoarthritis: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Effects of Sodium Hypochlorite Washing on Eggshell Membrane Integrity, Microbial Decontamination, and Trace Element-Related Dietary Risk in Poultry and Duck Eggs.Biological trace element research · 2026Article
- Clinical plausibility of eggshell membrane proteins for osteoarthritis: a study of solubility, digestibility, and immune response.Molecular and cellular biochemistry · 2026Article
- Enzymatically Hydrolyzed Eggshell Membrane Promotes Keratinocyte Differentiation Associated With PKC and Akt Signaling Pathways.Journal of food science · 2026Article
- Methodological estimation of pore size in hen eggshell membranes.BMC research notes · 2026Article
- Short Eggshell Membrane Nanofibers-Chitosan Hydrogel with Dual-Functional Hemostasis and Shape Memory for Non-Compressible Wounds.Gels (Basel, Switzerland) · 2026Article
- Scalable Jet-O-Mized Eggshell Membrane Processing for Bioactives Promoting Gut Health.Molecules (Basel, Switzerland) · 2026Article
- Article
- Design and optimization of a shearing grinding device for efficient separation of eggshell and eggshell membrane.Frontiers in bioengineering and biotechnology · 2026Article
- Development of molecularly imprinted vegetarian membranes (MIP-VMs) for oral tissue repair and regeneration.Frontiers in bioengineering and biotechnology · 2026Article
- Development of a Multilayer Film Including the Soluble Eggshell Membrane Fraction for the Treatment of Oral Mucosa Lesions.Pharmaceutics · 2024Article
- X-Ray Visible Protein Scaffolds by Bulk Iodination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eggshell membranes (ESM) contain 90% protein, 3% lipids, 2% sugars, and small amounts of minerals such as calcium and magnesium. Of the 90% of proteins present, 472 proteins species have been identified. ESM provide the initial mineralization platform for eggshell formation, and can be used for to produce adsorbents, cosmetics, and medical products because of their special physical structure and chemical composition. The special physical structure of the eggshell membrane, with disulfide bonds between and within the protein molecules and the cross-linking of lysine-derived and heterochain chains between the eggshell membrane, makes the membrane very difficult to dissolve, with a maximum solubility rate of only 62%. Also, the insolubility of ESM limits its development and use also any related research. Based on the physical structure and chemical composition of the eggshell membrane, this paper reviews the latest research on eggshell membrane separation and membrane protein solubilization to provide a reference for promoting the separation, dissolution, and rational development and use of the avian eggshell membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.