Evidence map›Paper›PMID 37008154›Full record

ArticleACS omega2023

Probing the Allosteric Modulation of P-Glycoprotein: A Medicinal Chemistry Approach Toward the Identification of Noncompetitive P-Gp Inhibitors.

Cátia A Bonito, Ricardo J Ferreira, Maria-José U Ferreira, Fernando Durães, Emília Sousa, Jean-Pierre Gillet, M Natália D S Cordeiro, Daniel J V A Dos Santos

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. The Antidepressant Drug Clomipramine Inhibits the ABC Transporter BmrA.Chembiochem : a European journal of chemical biology · 2026
    Article
  2. Article
  3. Article
  4. Acridine-Based Chalcone 1C and ABC Transporters.International journal of molecular sciences · 2025
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Cátia A BonitoLAQV@REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, Porto 4169-007, Portugal.ORCID https://orcid.org/0000-0003-3863-3033
Ricardo J FerreiraRed Glead Discovery AB, Medicon Village, Scheelevägen 8, Lund 223 63, Sweden.ORCID https://orcid.org/0000-0003-2590-8229
Maria-José U FerreiraResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisbon 1649-003, Portugal.
Fernando DurãesInterdisciplinary Centre of Marine and Environmental Research (CIIMAR) & Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal.
Emília SousaInterdisciplinary Centre of Marine and Environmental Research (CIIMAR) & Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal.ORCID https://orcid.org/0000-0002-5397-4672
Jean-Pierre GilletLaboratory of Molecular Cancer Biology, URPhyM, NARILIS, Faculty of Medicine, University of Namur, Namur 5000, Belgium.
M Natália D S CordeiroLAQV@REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, Porto 4169-007, Portugal.ORCID https://orcid.org/0000-0003-3375-8670
Daniel J V A Dos SantosCBIOS-Center for Research in Biosciences & Health Technologies, Lusófona University, Campo Grande, 376, Lisboa 1749-024, Portugal.ORCID https://orcid.org/0000-0001-7798-8641
Universidade do Porto · PTMedicon Village · SEUniversidade Lusófona · PTUniversity of Lisbon · PTUniversity of Namur · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A medicinal chemistry approach combining

Identifiers

PMID37008154
PMCPMC10061618
OpenAlexW4324134363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.