ArticleFrontiers in physiology2023
Discrimination between human normal renal tissue and renal cell carcinoma by dielectric properties using
Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Development and Validation in Porcine and Human Models of a Bioimpedance Spectroscopy System for the Objective Assessment of Kidney Graft Viability.Sensors (Basel, Switzerland) · 2025Article
- Reproducibility analysis of bioimpedance-based self-developed live cell assays.Scientific reports · 2024Article
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5 authors.
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Abstract
Renal cell carcinoma (RCC) poses a serious threat to human health, which urgently requires a method that can quickly distinguish between human normal renal tissue (NRT) and RCC for the purpose of accurate detection in clinical practice. The significant difference in cell morphology between NRT and RCC tissue underlies the great potential of the bioelectrical impedance analysis (BIA) to distinguish two types of human tissues. The study aims to achieve such discrimination through comparison of their dielectric properties within the frequency range from 10 Hz to 100 MHz. The dielectric properties of 69 cases of human normal and cancer renal tissue were measured 15 min after tissue isolation in a strictly controlled environment (37°C, 90% humidity). In addition to the impedance parameters (resistivity, conductivity and relative permittivity), the characteristic parameters extracted from the Cole curve were also compared between NRT and RCC. Furthermore, a novel index, distinguishing coefficient (DC), was used to obtain the optimal frequency for discrimination between NRT and RCC. In terms of impedance parameters, the RCC conductivity at low frequencies (<1 kHz) was about 1.4 times as large as that of NRT, and its relative permittivity was also significantly higher (
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