Evidence map›Paper›PMID 37007646›Full record

ArticleOphthalmology science2023

No Strong Association between the Apolipoprotein E E4 Allele and Glaucoma: A Multicohort Study.

Sean Mullany, Santiago Diaz-Torres, Joshua M Schmidt, Daniel Thomson, Ayub Qassim, Henry N Marshall, Lachlan S W Knight, Ella C Berry, Antonia Kolovos, David Dimasi and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. International journal of molecular sciences · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 1 country.

Sean MullanyDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Santiago Diaz-TorresDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Joshua M SchmidtDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Daniel ThomsonDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Ayub QassimDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Henry N MarshallDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Lachlan S W KnightDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Ella C BerryDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Antonia KolovosDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
David DimasiDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Stewart LakeDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Richard A MillsDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
John LandersDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Paul MitchellCentre for Vision Research, University of Sydney, Sydney, Australia.
Paul R HealeyCentre for Vision Research, University of Sydney, Sydney, Australia.
Toby CommerfordDepartment of Geriatric Medicine, Royal Adelaide Hospital, Adelaide, South Australia.
Sonja KlebeDepartment of Pathology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Emmanuelle SouzeauDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Mark M HassallDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Stuart MacGregorDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Puya GharahkhaniDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Owen M SiggsDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Jamie E CraigDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia.
Flinders University · AUQIMR Berghofer Medical Research Institute · AUThe University of Sydney · AUGarvan Institute of Medical Research · AURoyal Adelaide Hospital · AU

Funding

Wellcome Trust
6 · The paper itself

Abstract

Purpose: To elucidate a potential association between the apolipoprotein E ( Design: A cross-sectional analysis of baseline and prospectively collected cohort data. Participants: UK Biobank (UKBB) participants of genetically determined European ancestry (n = 438 711). Replication analyses were performed using clinical and genotyping data collected from European participants recruited to the Canadian Longitudinal Study of Aging (CLSA; n = 18 199), the Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG; n = 1970), and the Blue Mountains Eye Study (BMES; n = 2440). Methods: Apolipoprotein E alleles and genotypes were determined, and their distributions were compared on the basis of glaucoma status. Similar analyses were performed using positive control outcomes associated with the Main Outcome Measures: Results of Results: The Conclusions: A small negative association observed between Financial Disclosures: The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Indexed as

Alzheimer’s dementiaAPOEApolipoprotein EGlaucomaPOAG

Identifiers

PMID37007646
PMCPMC10064233
OpenAlexW4320487388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.