Evidence map›Paper›PMID 37007605›Full record

ArticleMicrosystems & nanoengineering2023

Sperm quality metrics were improved by a biomimetic microfluidic selection platform compared to swim-up methods.

Steven A Vasilescu, Lin Ding, Farin Yazdan Parast, Reza Nosrati, Majid Ebrahimi Warkiani

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Article in Microsystems & nanoengineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  6. [Screening of High-quality Spermatozoa Using Transwell Membrane Pores and Assessment of Their Performance].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
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  10. In vitro models of the male reproductive system: applications for developmental and reproductive toxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Steven A VasilescuNeoGenix Biosciences pty ltd, Sydney, NSW 2126 Australia.
Lin DingSchool of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007 Australia.
Farin Yazdan ParastDepartment of Mechanical & Aerospace Engineering, Monash University, Clayton, VIC 3800 Australia.
Reza NosratiDepartment of Mechanical & Aerospace Engineering, Monash University, Clayton, VIC 3800 Australia.ORCID 0000-0002-1461-229X
Majid Ebrahimi WarkianiSchool of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007 Australia.ORCID 0000-0002-4184-1944

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sperm selection is an essential component of all assisted reproductive treatments (ARTs) and is by far the most neglected step in the ART workflow in regard to technological innovation. Conventional sperm selection methodologies typically produce a higher total number of sperm with variable motilities, morphologies, and levels of DNA integrity. Gold-standard techniques, including density gradient centrifugation (DGC) and swim-up (SU), have been shown to induce DNA fragmentation through introducing reactive oxygen species (ROS) during centrifugation. Here, we demonstrate a 3D printed, biologically inspired microfluidic sperm selection device (MSSP) that utilizes multiple methods to simulate a sperms journey toward selection. Sperm are first selected based on their motility and boundary-following behavior and then on their expression of apoptotic markers, yielding over 68% more motile sperm than that of previously reported methods with a lower incidence of DNA fragmentation and apoptosis. Sperm from the MSSP also demonstrated higher motile sperm recovery after cryopreservation than that of SU or neat semen. Experiments were conducted side-by-side against conventional SU methods using human semen (

Indexed as

EngineeringMaterials science

Identifiers

PMID37007605
PMCPMC10050147

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read106
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.