ArticleAnnals of translational medicine2023
Early administration of mucoactive agents and ventilator-free days: a propensity score-matched study.
Article in Annals of translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Catalase: A Potential Pharmacologic Target for Hydrogen Peroxide in the Treatment of COVID-19.Current topics in medicinal chemistry · 2024Pooled it
- Association between early administration of mucoactive agents and in-hospital mortality in patients with pneumonia requiring mechanical ventilation: a nationwide cohort study.Journal of intensive care · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Background: Mucoactive agents are often prescribed for the management of airway secretions. However, it is unclear whether they improve respiratory outcomes in mechanically ventilated patients. Methods: We examined the association between the early administration of mucoactive agents in ventilated patients and increased ventilator-free days (VFDs). This retrospective observational study was conducted in two intensive care units (ICUs) of a tertiary care hospital in Japan. We applied 1:1 propensity score matching between the early mucoactive agent group and the on-demand mucoactive agent group. We compared VFDs during the first 28 days of ICU stay as the primary outcome between the groups. Results: In total, 662 participants were eligible for this study, and 94 participants (47 in each group) were included in the analysis. There was no difference in the median VFDs between the groups [21 days; interquartile (IQR) 1-24 for the early group Conclusions: Early administration of mucoactive agents was not associated with increased VFDs.
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