ArticleAlpha psychiatry2021
Use of Methylphenidate in Coexisting Major Depression, Loss of Libido and Erectile Dysfunction.
Article in Alpha psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- The Impact of Methylphenidate on Sexual Functions: A Systematic Review of Benefits and Risks.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans: an overview of recent findings.Neural regeneration research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erectile dysfunction and low sexual desire in males are frequently encountered sexual function disorders. Reduced sexual desire or libido is defined as the low frequency of sexual union or achieving orgasm and reduced motivation to initiate or respond to a sexual activity. Individuals with major depression are very frequently observed to have sexual function disorders. It is known that antidepressant agents used for depression treatment are insufficient to regulate sexual function disorder most of the time, whereas some antidepressant agents themselves have side effects of developing a sexual function disorder. Methylphenidate, frequently used for attention-deficit and hyperactivity disorder, is known to affect sexual behavior. Methylphenidate increases dopamine (DA) and norepinephrine (NE) neurotransmission through DA and NE reuptake inhibition. Increases in DA have long been known to increase sexual desire. This article presents the case of a 40-year-old male patient treated with antidepressants who had improvements in erectile dysfunction and loss of libido accompanying depression with the addition of methylphenidate to the treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.