Evidence map›Paper›PMID 37006723›Full record

ArticleDrug design, development and therapy2023

Investigating the Mechanism of Action of

Sihua Wen, Kai Yang, Yunfeng Bai, Yanan Wu, Ding Liu, Xu Wu, Xiaofei Zhang, Jing Sun

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sihua Wen *Department of Pharmaceutics, The Key Laboratory of Basic and New Drug Research of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, People's Republic of China.
Kai Yang *Department of Pharmaceutics, The Key Laboratory of Basic and New Drug Research of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, People's Republic of China.
Yunfeng BaiShaanxi Dongtai Pharmaceutical Co., Ltd, Shaanxi, People's Republic of China.
Yanan WuDepartment of Pharmaceutics, The Key Laboratory of Basic and New Drug Research of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, People's Republic of China.
Ding LiuDepartment of Pharmaceutics, The Key Laboratory of Basic and New Drug Research of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, People's Republic of China.
Xu WuDepartment of Pharmaceutics, The Key Laboratory of Basic and New Drug Research of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, People's Republic of China.
Xiaofei ZhangDepartment of Pharmaceutics, The Key Laboratory of Basic and New Drug Research of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, People's Republic of China.
Jing SunDepartment of Pharmaceutics, The Key Laboratory of Basic and New Drug Research of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang, People's Republic of China.
Shaanxi University of Chinese Medicine · CNLuye Pharma (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To study the active components, drug targets and mechanism of Methods: Network pharmacology combined with the gene expression omnibus chip method to analyze the main pathways by which Results: Network pharmacology combined with experimental validation suggests that the mechanism of action of Conclusion: The therapeutic effect of

Indexed as

Drugs, Chinese HerbalHeart FailureSchisandraAnimalsMolecular Docking SimulationPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleyUbiquinonecoenzyme Q10Drugs, Chinese HerbalPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktUbiquinonecoenzyme Q10heart failuremechanism validationmolecular dockingnetwork pharmacologySchisandra chinensis

Identifiers

PMID37006723
PMCPMC10065024
OpenAlexW4361010894

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.