Evidence map›Paper›PMID 37006483›Full record

ArticleFrontiers in neurology2023

Implications of quantitative susceptibility mapping at 7 Tesla MRI for microbleeds detection in cerebral small vessel disease.

Valentina Perosa, Johanna Rotta, Renat Yakupov, Hugo J Kuijf, Frank Schreiber, Jan T Oltmer, Hendrik Mattern, Hans-Jochen Heinze, Emrah Düzel, Stefanie Schreiber

Open access · goldFull text read
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  6. Enlarged perivascular spaces in the basal ganglia are associated with arteries not veins.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Valentina PerosaJ. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston, MA, United States.
Johanna RottaDepartment of Neurology, Otto-von-Guericke University, Magdeburg, Germany.
Renat YakupovInstitute of Cognitive Neurology and Dementia Research (IKND), Magdeburg, Germany.
Hugo J KuijfImage Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands.
Frank SchreiberDepartment of Neurology, Otto-von-Guericke University, Magdeburg, Germany.
Jan T OltmerAthinoula A. Martinos Center, Massachusetts General Hospital, Department of Radiology, Boston, MA, United States.
Hendrik MatternGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Hans-Jochen HeinzeDepartment of Neurology, Otto-von-Guericke University, Magdeburg, Germany.
Emrah DüzelInstitute of Cognitive Neurology and Dementia Research (IKND), Magdeburg, Germany.
Stefanie SchreiberDepartment of Neurology, Otto-von-Guericke University, Magdeburg, Germany.
German Center for Neurodegenerative Diseases · DEOtto-von-Guericke University Magdeburg · DEAthinoula A. Martinos Center for Biomedical Imaging · USMassachusetts General Hospital · USUniversity College London · GBUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cerebral microbleeds (MBs) are a hallmark of cerebral small vessel disease (CSVD) and can be found on T2 Aims: We explored the implications of using QSM at submillimeter resolution for MBs detection in CSVD. Methods: Both 3 and 7 Tesla (T) MRI were performed in elderly participants without MBs and patients with CSVD. MBs were quantified on T2 Results: 48 participants [mean age (SD) 70.9 (8.8) years, 48% females] were included: 31 were healthy controls, 6 probable cerebral amyloid angiopathy (CAA), 9 mixed CSVD, and 2 were hypertensive arteriopathy [HA] patients. After accounting for the higher number of MBs detected at 7T QSM (Median = Mdn; Mdn Conclusions: Our observations suggest that QSM at submillimeter resolution improves the detection of MBs in the elderly human brain. A higher prevalence of MBs than so far known in healthy elderly was revealed.

Indexed as

7 Tesla MRIcerebral amyloid angiopathy (CAA)cerebral small vessel disease (CSVD)hypertensive arteriopathy (HA)microbleedsquantitative susceptibility mapping (QSM)

Identifiers

PMID37006483
PMCPMC10050564
OpenAlexW4324378539

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.