ArticleFrontiers in neurology2023
Associations of macular microvascular parameters with cerebral small vessel disease in rural older adults: A population-based OCT angiography study.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Retinal Optical Coherence Tomography-Angiography and Longitudinal Changes in Cognition and Cerebral Small Vessel Disease.Neurology · 2026Article
- Ultra-widefield OCTA assessment of retinal and choroidal microcirculation in cerebral small vessel disease.Scientific reports · 2026Article
- Retinal vessel density and cognitive function in healthy older adults.Experimental brain research · 2025Article
- Insight into the Brain: Application of the Retinal Microvasculature as a Biomarker for Cerebrovascular Diseases through Optical Coherence Tomography Angiography.Current ophthalmology reports · 2024Article
- The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study.Quantitative imaging in medicine and surgery · 2024Article
- Peripapillary vessels density is closely related to cerebral white matter hyperintensities: An OCTA study.PloS one · 2024Article
- Retinal structure and vessel density changes in cerebral small vessel disease.Frontiers in neuroscience · 2024Article
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15 authors.
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Abstract
Objective: To explore the associations of macular microvascular parameters with cerebral small vessel disease (CSVD) in rural-dwelling older adults in China. Methods: This population-based cross-sectional study included 195 participants (age ≥ 60 years; 57.4% women) in the optical coherence tomographic angiography (OCTA) sub-study within the Multimodal Interventions to delay Dementia and disability in rural China (MIND-China). Macular microvascular parameters were measured using the OCTA. We automatically estimated volumes of gray matter, white matter, and white matter hyperintensity (WMH), and manually assessed numbers of enlarged perivascular spaces (EPVS) and lacunes on brain magnetic resonance imaging. Data were analyzed with the general linear models. Results: Adjusting for multiple confounders, lower vessel skeleton density (VSD) and higher vessel diameter index (VDI) were significantly associated with larger WMH volume ( Conclusion: Macular microvascular signs are associated with WMH, brain parenchymal volume, and EPVS in older adults. The OCTA-assessed macular microvascular parameters can be valuable markers for microvascular lesions in the brain.
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