Evidence map›Paper›PMID 37006314›Full record

ArticleFrontiers in immunology2023

A chemokine network of T cell exhaustion and metabolic reprogramming in renal cell carcinoma.

Renate Pichler, Peter J Siska, Piotr Tymoszuk, Agnieszka Martowicz, Gerold Untergasser, Roman Mayr, Florian Weber, Andreas Seeber, Florian Kocher, Dominik A Barth and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. The role of CD8Frontiers in immunology · 2026
    Pooled it
  2. CXCL13-expressing CD4Oncoimmunology · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Exhausted CD4Frontiers in immunology · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. The multifaceted role of XCL1 in health and disease.Protein science : a publication of the Protein Society · 2025
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Renate PichlerDepartment of Urology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.
Peter J SiskaDepartment of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.
Piotr TymoszukData Analytics As a Service Tirol, Innsbruck, Austria.
Agnieszka MartowiczDepartment of Internal Medicine V (Hematology and Oncology), Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.
Gerold UntergasserDepartment of Internal Medicine V (Hematology and Oncology), Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.
Roman MayrDepartment of Urology, Caritas St. Josef Medical Centre, University of Regensburg, Regensburg, Germany.
Florian WeberDepartment of Pathology, University of Regensburg, Regensburg, Germany.
Andreas SeeberDepartment of Internal Medicine V (Hematology and Oncology), Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.
Florian KocherDepartment of Internal Medicine V (Hematology and Oncology), Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.
Dominik A BarthDivision of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Martin PichlerDivision of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Martin ThurnherImmunotherapy Unit, Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.
Innsbruck Medical University · ATMedical University of Graz · ATUniversity of Regensburg · DEUniversity Hospital Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal cell carcinoma (RCC) is frequently infiltrated by immune cells, a process which is governed by chemokines. CD8

Indexed as

Carcinoma, Renal CellKidney NeoplasmsCD8-Positive T-LymphocytesChemokine CXCL9ChemokinesHumansT-Cell ExhaustionTumor MicroenvironmentChemokine CXCL9ChemokineschemokinesIDO, biomarkerimmunotherapymetabolismOXPHOSRCCT cells

Identifiers

PMID37006314
PMCPMC10060976
OpenAlexW4327618035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.