Evidence map›Paper›PMID 37005958›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2023

Non-conventional laryngeal malignancies: a multicentre review of management and outcomes.

Rory J O'Neill, Justin Hintze, Adrinda Sharifah, Stephen Garry, Graham Woods, Anthony Noone, Helen L Barrett, Orla Young, Sherif Mamdouh, Neville Shine and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The histopathological spectrum of laryngeal epithelial neoplasia.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rory J O'NeillDepartment of Otorhinolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland. oneillrjj@gmail.com.ORCID http://orcid.org/0000-0003-4021-9325
Justin HintzeDepartment of Otorhinolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland.
Adrinda SharifahDepartment of Otorhinolaryngology, Head and Neck Surgery, St James Hospital, Dublin, Ireland.
Stephen GarryRoyal College of Surgeons, Dublin, Ireland.
Graham WoodsDepartment of Histopathology, Beaumont Hospital, Dublin, Ireland.
Anthony NooneDepartment of Otorhinolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland.
Helen L BarrettDepartment of Otorhinolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland.
Orla YoungDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Galway, Galway, Ireland.
Sherif MamdouhDepartment of Otorhinolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland.
Neville ShineDepartment of Otorhinolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland.
Conrad TimonDepartment of Otorhinolaryngology, Head and Neck Surgery, St James Hospital, Dublin, Ireland.
John KinsellaDepartment of Otorhinolaryngology, Head and Neck Surgery, St James Hospital, Dublin, Ireland.
Patrick SheahanDepartment of Otorhinolaryngology, Head and Neck Surgery, South Infirmary Victoria University Hospital, Cork, Ireland.
Paul LennonDepartment of Otorhinolaryngology, Head and Neck Surgery, St James Hospital, Dublin, Ireland.
James Paul O'NeillDepartment of Otorhinolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNon-conventional laryngeal malignancies (NSCC) often have limited published data to guide management despite individual histopathological subtypes often exhibiting heterogeneous behaviour, characteristics, and treatment responses compared to laryngeal squamous cell carcinoma (SCC). This study aimed to compare oncological outcomes with SCC, specifically disease-free survival (DFS), disease-specific survival (DSS) and overall survival (OS). Secondary objectives were to compare treatment differences and perform a state of the art review.

methodsThis was a multicentre retrospective cohort study at four tertiary head and neck centres. Survival outcomes between NSCC and SCC patients were analysed with Kaplan-Meier curves and compared by log rank testing. Univariate Cox regression analysis was performed to predict survival by histopathological subgroup, T-stage, N-stage and M-stage.

resultsThere were no significant differences in 3-year DFS (p = 0.499), DSS (p = 0.329), OS (p = 0.360) or Kaplan Meier survival curves (DSS/OS) between SCC and overall NSCC groups. However, univariate Cox regression analysis identified "rare" histopathologies (mostly small cell carcinoma) to be predictive of less favourable OS (p = 0.035) but this result was not observed for other NSCC histopathological subgroups. N-stage (p = 0.027) and M-stage (p = 0.048) also predicted OS for NSCC malignancies. Significant differences in treatment modalities were identified with treatment of NSCC typically involving surgical resection and SCC often managed non-surgically (e.g., primary radiotherapy).

conclusionsAlthough overall NSCC is managed differently compared to SCC, there do not appear to be differences in survival outcomes between these groups. N-stage and M-stage appear to be more predictive of OS than histopathology than many NSCC subtypes.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsLaryngeal NeoplasmsHumansNeoplasm StagingPrognosisRetrospective StudiesHead and neckLaryngeal cancerOncologyOutcomesRadiotherapySurgery

Identifiers

PMID37005958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.