ArticleInsights into imaging2023
Opportunistic screening for osteoporosis by abdominal CT in a British population.
Article in Insights into imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Computed tomography-measured trabecular attenuation at first lumbar vertebra as a surrogate marker of bone mineral density and osteoporosis in patients undergoing hemodialysis.Renal failure · 2026Article
- Opportunistic Screening for Bone Demineralization by Whole Body CT in a Red-Handed Howler Monkey (Alouatta belzebul) Under Human Care.Journal of medical primatology · 2026Article
- Multi-center validation of automated CT-based L1 vertebral Hounsfield unit.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Multisite opportunistic osteoporosis screening in polytrauma : Vertebral, femoral, and dentomaxillofacial markers.Radiologie (Heidelberg, Germany) · 2026Article
- Consensus statement on the application of artificial intelligence in osteoporosis screening and management: perspectives from the Asia-Pacific region.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Residential altitude was not independently associated with osteoporosis among long-term Qinghai-Tibetan Plateau residents.Frontiers in public health · 2026Article
- Opportunistic computed tomography assessment of bone, muscle, and adipose tissue: evidence, limitations, and clinical translation.Frontiers in medicine · 2026Review
- The association between bone density evaluated on CT or MRI versus the gold standard dual-energy X-ray absorptiometry (DEXA) in the lumbar spine and hip: a meta-analysis.Brain & spine · 2026Review
- Evaluating Bone Mass with Opportunistic Chest CT: T8 as the Optimal Vertebral Level.Calcified tissue international · 2025Article
- CT-based hounsfield unit as an alternative osteoporosis assessment in ankylosing spondylitis patients with bamboo spine.Scientific reports · 2025Article
- Opportunistic screening of osteoporosis in lung transplant recipients: diagnostic value of pre-transplant thoracic CT using vertebral Hounsfield units.Journal of orthopaedic surgery and research · 2025Article
- A Pan-Organ Vision-Language Model for Generalizable 3D CT Representations.medRxiv : the preprint server for health sciences · 2025Article
- Quantification of the difference in hounsfield units of an electron density phantom between a conventional and standing computed tomography machine.Veterinary research communications · 2025Article
- Hounsfield units predict vertebral compression fractures in gastric cancer survivors after adjuvant irradiation.Radiation oncology journal · 2025Article
- Assessment of trabecular bone Hounsfield units in the lumbar spine for osteoporosis evaluation in individuals aged 65 and above: a review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- Opportunistic screening for osteoporosis using routine clinical care computed tomography brain studies.Skeletal radiology · 2025Article
- Comparison of thoracic vertebrae and L1 CT attenuation in predicting osteoporosis using opportunistic chest CT.Therapeutic advances in musculoskeletal disease · 2025Article
- Regional variations and spatial heterogeneity of lumbar CT attenuation are associated with osteoporotic vertebral fracture.Frontiers in endocrinology · 2025Article
- Metabolic phenotyping with computed tomography deep learning for metabolic syndrome, osteoporosis and sarcopenia predicts mortality in adults.Journal of cachexia, sarcopenia and muscle · 2024Article
- Coronal plane in opportunistic screening of osteoporosis using computed tomography: comparison with axial and sagittal planes.Skeletal radiology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has previously been shown that CT scans performed for other indications can be used to identify patients with osteoporosis. This has not yet been tested in a British population. We sought to evaluate the use of vertebral CT attenuation measures for predicting osteoporosis in a British cohort, using dual-energy X-ray absorptiometry (DEXA) as a reference standard.
methodsPatients who underwent abdominal CT in 2018 and concomitantly underwent DEXA within a six-month interval were retrospectively included. CT attenuation values in Hounsfield units (HU) were measured by placement of a region-of-interest at the central portion of the L1 vertebral body and then compared to their corresponding DEXA score. Receiver operating characteristic (ROC) curves were generated to evaluate the performance of a logistic regression model and to determine sensitivity and specificity thresholds.
results536 patients (394 females, mean age 65.8) were included, of which 174 had DEXA-defined osteoporosis. L1 attenuation measures were significantly different (p < 0.01) between the three DEXA-defined groups of osteoporosis (118 HU), osteopenia (143 HU) and normal bone density (178 HU). The area under the ROC curve was 0.74 (95% CI 0.69-0.78). A threshold of 169 HU was 90% sensitive, and a threshold of 104 HU was 90% specific for diagnosing osteoporosis.
conclusionsRoutine abdominal CT can be used to opportunistically screen for osteoporosis without additional cost or radiation exposure. The thresholds identified in this study are comparable with previous studies in other populations. We recommend radiologists engage with primary care and rheumatology providers to determine appropriate cut-off values for further investigation.
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