Evidence map›Paper›PMID 37005645›Full record

ArticleItalian journal of pediatrics2023

Association of preterm outcome with maternal systemic lupus erythematosus: a retrospective cohort study.

Xiafang Chen, Wen Di, Lili Ye, Yabin Hu, Meng Jiang, Jiayue Wu, Jun Bu, Jianhua Sun, Fei Bei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiafang ChenDepartment of Neonatology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 DongFang Road, 200127, Shanghai, China.
Wen DiDepartment of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Lili YeDepartment of Rheumatology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yabin HuDepartment of Clinical Epidemiology and Biostatistics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Meng JiangDepartment of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jiayue WuDepartment of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jun BuDepartment of Neonatology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 DongFang Road, 200127, Shanghai, China.
Jianhua SunDepartment of Neonatology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 DongFang Road, 200127, Shanghai, China.
Fei BeiDepartment of Neonatology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 DongFang Road, 200127, Shanghai, China. beifei@scmc.com.cn.
Shanghai Jiao Tong University · CNShanghai Children's Medical Center · CN

Funding

Clinical research project of Shanghai Children's Medical Center Clinical research project of Shanghai Children's Medical CenterShanghai Municipal Health Commissio Shanghai Municipal Health Commissio
6 · The paper itself

Abstract

backgroundMaternal systemic lupus erythematosus (SLE) is at greater risk of pregnancy complications and is associated with increased risk of preterm delivery. However hardly any study has looked at the influence of SLE on the outcomes of preterm infants. This study aimed to explore the influence of SLE on the outcomes of preterm infants.

methodsIn this retrospective cohort study, preterm infants born to mothers with SLE from Shanghai Children's Medical Center during 2012 to 2021 were enrolled. Infants were excluded if they were died during hospitalization or has major congenital anomalies and neonatal lupus. Exposure was defined as mother diagnosed SLE before or during pregnancy. Maternal SLE group was matched with Non-SLE group by gestational age, birth weight and gender. Clinical data has been extracted from patients' records and registered. Major morbidities of premature and biochemical parameters in the two groups were compared using multiple logistic regression.

resultsOne hundred preterm infants born to 95 mothers with SLE were finally enrolled. The mean (standard deviation) of gestational age and birth weight were 33.09 (7.28) weeks and 1768.50 (423.56) g respectively. There was no significant difference in major morbidities between SLE group and non-SLE group. Compared with non-SLE group, SLE off-spring had significantly lower leukocytes, neutrophiles after birth, neutrophils and platlet in one week (mean difference: -2.825, -2.001, -0.842, -45.469, respectively). Among SLE group, lower birth weight and smaller gestational age were observed in SLE mothers with disease active during pregnancy, kidney involved, blood system involved and not taking Aspirin during pregnancy. In the multivariable logistic regression analysis, exposure to aspirin during pregnancy reduced the risk of very preterm birth and increased the incidence of survive without major morbidities among preterm infants born to SLE mothers.

conclusionBorn to mothers with SLE may not increase the risk of major premature morbidities, but the hematologic profile of SLE preterm infants may be different from preterm infants born to women without SLE. The outcome of SLE preterm infants is associated with maternal SLE status and may benefit from maternal aspirin administration.

Indexed as

Lupus Erythematosus, SystemicPremature BirthAspirinBirth WeightChildChinaFemaleHumansInfantInfant, NewbornInfant, PrematurePregnancyPregnancy OutcomeRetrospective StudiesAspirinPremature comorbiditiesPreterm infantsSLE

Identifiers

PMID37005645
PMCPMC10068147
OpenAlexW4362522476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.