Evidence map›Paper›PMID 37005597›Full record

ArticleJournal of neurodevelopmental disorders2023

Neurophysiological measures of auditory sensory processing are associated with adaptive behavior in children with Autism Spectrum Disorder.

Mairin Cotter, Seydanur Reisli, Ana Alves Francisco, Kathryn-Mary Wakim, Leona Oakes, Michael J Crosse, John J Foxe, Sophie Molholm

Open access · goldAbstract read
In one paragraph

Article in Journal of neurodevelopmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. How auditory processing influences the autistic profile: A review.Autism research : official journal of the International Society for Autism Research · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mairin CotterThe Cognitive Neurophysiology Laboratory, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Seydanur ReisliThe Cognitive Neurophysiology Laboratory, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Ana Alves FranciscoThe Cognitive Neurophysiology Laboratory, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Kathryn-Mary WakimThe Cognitive Neurophysiology Laboratory, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Leona OakesThe Cognitive Neurophysiology Laboratory, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Michael J CrosseSegotia, Galway, Ireland.
John J FoxeThe Cognitive Neurophysiology Laboratory, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Sophie MolholmThe Cognitive Neurophysiology Laboratory, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. sophie.molholm@einsteinmed.edu.
Albert Einstein College of Medicine · USTrinity College Dublin · IEUniversity of Rochester · US

Funding

SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Sensory Processing and Integration in AutismR01MH085322 · NIMH · CITY COLLEGE OF NEW YORK · PI FOXE, JOHN J, MOLHOLM, SOPHIE · 2009 to 2013
$2.8M
Training in Intellectual and Developmental Disabilities (IDD) ResearchT32HD098067 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MOLHOLM, SOPHIE, WALKLEY, STEVEN UPSHAW · 2020 to 2024
$1.3M
NICHD NIH HHS P50 HD105352NICHD NIH HHS T32 HD098067NIMH NIH HHS R01 MH085322
6 · The paper itself

Abstract

backgroundAtypical auditory cortical processing is consistently found in scalp electrophysiological and magnetoencephalographic studies of Autism Spectrum Disorder (ASD), and may provide a marker of neuropathological brain development. However, the relationship between atypical cortical processing of auditory information and adaptive behavior in ASD is not yet well understood.

methodsWe sought to test the hypothesis that early (100-175 ms) auditory processing in ASD is related to everyday adaptive behavior through the examination of auditory event-related potentials (AEPs) in response to simple tones and Vineland Adaptive Behavior Scales in a large cohort of children with ASD (N = 84), aged 6-17, and in age- and IQ- matched neurotypically (NT) developing controls (N = 132).

resultsStatistical analyses revealed significant group differences in early AEPs over temporal scalp regions (150-175 ms), and the expected rightward lateralization of the AEP (100-125 ms and 150-175 ms) to tonal stimuli in both groups. Lateralization of the AEP (150-175 ms) was significantly associated with adaptive functioning in the socialization domain.

conclusionsThese results lend support to the hypothesis that atypical processing of sensory information is related to everyday adaptive behavior in autism.

Indexed as

Autism Spectrum DisorderAdaptation, PsychologicalAuditory PerceptionChildEvoked PotentialsHumansMagnetoencephalographyAdaptive behaviorAuditory processingAutism Spectrum DisorderElectroencephalographyEvent related potentialsLateralization

Identifiers

PMID37005597
PMCPMC10068141
OpenAlexW4362523123

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.