ArticleNPJ Parkinson's disease2023
Dopamine facilitates the translation of physical exertion into assessments of effort.
Article in NPJ Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder.Biological psychiatry global open science · 2026Article
- Increased exertion variability is linked to disruptions in effort assessment in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Why Do Humans Exercise? A Neuro-Evolutionary Framework for Discretionary Physical Effort.Evolutionary anthropology · 2026Review
- Environmental uncertainty shapes human effort learning.PLoS biology · 2026Article
- Computational signatures of exertion and rest underlie moment-to-moment dynamics of subjective perceptions of effort and fatigue.Cognitive, affective & behavioral neuroscience · 2026Article
- The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural mechanisms underlying the effects of cognitive fatigue on physical effort-based choice.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
Our assessments of effort are critically shaped by experiences of exertion. However, it is unclear how the nervous system transforms physical exertion into assessments of effort. Availability of the neuromodulator dopamine influences features of motor performance and effort-based decision-making. To test dopamine's role in the translation of effortful exertion into assessments of effort, we had participants with Parkinson's disease, in dopamine depleted (OFF dopaminergic medication) and elevated (ON dopaminergic medication) states, exert levels of physical exertion and retrospectively assess how much effort they exerted. In a dopamine-depleted state, participants exhibited increased exertion variability and over-reported their levels of exertion, compared to the dopamine-supplemented state. Increased exertion variability was associated with less accurate effort assessment and dopamine had a protective influence on this effect, reducing the extent to which exertion variability corrupted assessments of effort. Our findings provide an account of dopamine's role in the translation of features of motor performance into judgments of effort, and a potential therapeutic target for the increased sense of effort observed across a range of neurologic and psychiatric conditions.
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Registered trials
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