Evidence map›Paper›PMID 37005268›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Pneumocystis Pneumonia Infection Following the Initiation of Pembrolizumab Therapy for Lung Adenocarcinoma.

Toshiyuki Sumi, Kazuya Takeda, Haruhiko Michimata, Daiki Nagayama, Yuta Koshino, Hiroki Watanabe, Yuichi Yamada, Kentaro Kodama, Hirotaka Nishikiori, Hirofumi Chiba

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Toshiyuki SumiDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan.
Kazuya TakedaDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan.
Haruhiko MichimataDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan.
Daiki NagayamaDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan.
Yuta KoshinoDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan.
Hiroki WatanabeDepartment of Pulmonary Medicine, Hakodate Goryoukaku Hospital, Japan.
Yuichi YamadaDepartment of Pulmonary Medicine, Hakodate Goryoukaku Hospital, Japan.
Kentaro KodamaDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan.
Hirotaka NishikioriDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan.
Hirofumi ChibaDepartment of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan.
Sapporo Medical University · JPHakodate National Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pneumocystis pneumonia (PCP) is an opportunistic infection that presents a ground-glass appearance in the lungs on chest radiography. Interstitial lung disease is a commonly reported adverse effect of immune checkpoint inhibitor (ICI) treatment; however, there are few reports of ICI treatment-associated PCP infection. A 77-year-old man with lung adenocarcinoma was administered pembrolizumab and hospitalized for dyspnea 2 weeks after treatment. Chest computed tomography showed bilateral ground-glass opacities in all lung lobes. PCP was therefore diagnosed, and steroids and sulfamethoxazole-trimethoprim were initiated. Following treatment, the patient's condition improved promptly. This report suggests that ICI treatment can cause PCP infection.

Indexed as

Adenocarcinoma of LungLung NeoplasmsPneumocystis cariniiPneumonia, PneumocystisAgedAntibodies, Monoclonal, HumanizedHumansMaleAntibodies, Monoclonal, Humanizedpembrolizumabchest X-raydifferential diagnosisground-glass opacityimmunotherapyopportunistic infectionpneumocystis pneumonia

Identifiers

PMID37005268
PMCPMC10713372
OpenAlexW4362014314

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.