ArticleEBioMedicine2023
Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity.
Article in EBioMedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 80 citations in OpenAlex.
- Whole blood transcriptional signatures of age and survival identified in long life family and integrative longevity omics studies.GeroScience · 2026Article
- Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians.International journal of molecular sciences · 2026Review
- The long-lived immune system of centenarians.Nature reviews. Immunology · 2026Review
- Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts.JAMA network open · 2026Article
- Article
- Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures.Nature communications · 2026Article
- Bat-Inspired Longevity: Immune Damage Management and Nutritional Modulation for Healthy Aging.International journal of molecular sciences · 2026Review
- Age-related transcriptional drift and physiological adaptation in long-living Ames dwarf skeletal muscle.NAR molecular medicine · 2026Article
- The Immune Cell Atlas of "Longevity Molecular Tag": Identification of Principal Immune Cell Subsets and Their Underlying Molecular Regulatory Mechanisms.Aging cell · 2026Article
- Immune Ageing Clocks: A Methods-Oriented Review of Tasks, Modalities, Models, and Recalibration.Cells · 2026Review
- ERG phase separation attenuates cellular senescence.iScience · 2026Article
- Iron status modulates immune cell proportions to drive epigenetic age acceleration: A 2-step Mendelian randomization study.Medicine · 2026Article
- Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV.Aging · 2026Article
- Article
- Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity.Aging medicine (Milton (N.S.W)) · 2026Review
- Exploring phenotype-related single-cells through attention-enhanced representation learning.Genome medicine · 2026Article
- Centenarians: a model of immune resilience against multimorbidity.Life medicine · 2025Article
- Single-cell analysis of human thymus and peripheral blood unveils the dynamics of T cell development and aging.Nature aging · 2025Article
- Peripheral blood multimodal integration via cross-attention for cancer immune profiling.BMC cancer · 2025Article
- Osteoblast-CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAge-related changes in immune cell composition and functionality are associated with multimorbidity and mortality. However, many centenarians delay the onset of aging-related disease suggesting the presence of elite immunity that remains highly functional at extreme old age.
methodsTo identify immune-specific patterns of aging and extreme human longevity, we analyzed novel single cell profiles from the peripheral blood mononuclear cells (PBMCs) of a random sample of 7 centenarians (mean age 106) and publicly available single cell RNA-sequencing (scRNA-seq) datasets that included an additional 7 centenarians as well as 52 people at younger ages (20-89 years).
findingsThe analysis confirmed known shifts in the ratio of lymphocytes to myeloid cells, and noncytotoxic to cytotoxic cell distributions with aging, but also identified significant shifts from CD4
interpretationCollectively, these data suggest that centenarians harbor unique, highly functional immune systems that have successfully adapted to a history of insults allowing for the achievement of exceptional longevity.
fundingTK, SM, PS, GM, SA, TP are supported by NIH-NIAUH2AG064704 and U19AG023122. MM and PS are supported by NIHNIA Pepper center: P30 AG031679-10. This project is supported by the Flow Cytometry Core Facility at BUSM. FCCF is funded by the NIH Instrumentation grant: S10 OD021587.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.