Evidence map›Paper›PMID 37005080›Full record

ArticleBiomedical and environmental sciences : BES2023

Highly Sensitive Poly-N-isopropylacrylamide Microgel-based Electrochemical Biosensor for the Detection of SARS-COV-2 Spike Protein.

Hao Chen, Zhi Yuan Hou, Die Chen, Ting Li, Yi Ming Wang, Marcelo Andrade De Lima, Ying Yang, Zhen Zhong Guo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical and environmental sciences : BES, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Hao ChenDepartment of Anaesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
Zhi Yuan HouHubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, Hubei, China;Department of Pharmacy, Medical College, Wuhan University of Science and Technology Wuhan 430065, Hubei, China.
Die ChenHubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, Hubei, China;Department of Pharmacy, Medical College, Wuhan University of Science and Technology Wuhan 430065, Hubei, China.
Ting LiHubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, Hubei, China;Department of Pharmacy, Medical College, Wuhan University of Science and Technology Wuhan 430065, Hubei, China.
Yi Ming WangSchool of Public Health, Medical College, Wuhan University of Science and Technology Wuhan 430065, Hubei, China.
Marcelo Andrade De LimaSchool of Life Sciences, Keele University, Staffordshire ST5 5BG, UK.
Ying YangSchool of Pharmacy and Bioengineering, Keele University, Staffordshire ST4 7QB, UK.
Zhen Zhong GuoHubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, Hubei, China.
Wuhan University of Science and Technology · CNKeele University · GBTongji Hospital · CNWuhan College · CN

Funding

Wellcome Trust
6 · The paper itself

Abstract

Objective: Late 2019 witnessed the outbreak and widespread transmission of coronavirus disease 2019 (COVID-19), a new, highly contagious disease caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Consequently, considerable attention has been paid to the development of new diagnostic tools for the early detection of SARS-CoV-2. Methods: In this study, a new poly-N-isopropylacrylamide microgel-based electrochemical sensor was explored to detect the SARS-CoV-2 spike protein (S protein) in human saliva. The microgel was composed of a copolymer of N-isopropylacrylamide and acrylic acid, and gold nanoparticles were encapsulated within the microgel through facile and economical fabrication. The electrochemical performance of the sensor was evaluated through differential pulse voltammetry. Results: Under optimal experimental conditions, the linear range of the sensor was 10 Conclusion: The sensing platform exhibited excellent specificity and sensitivity in detecting spike protein, indicating its potential application for the time-saving and inexpensive detection of SARS-CoV-2.

Indexed as

COVID-19Metal NanoparticlesMicrogelsAcrylic ResinsGoldHumansSARS-CoV-2Spike Glycoprotein, CoronavirusAcrylic ResinsGoldMicrogelspoly-N-isopropylacrylamideSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2DetectionMicrogelSARS-CoV-2Spike protein

Identifiers

PMID37005080
PMCPMC10080711
OpenAlexW4362521985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.