ArticleCerebral cortex (New York, N.Y. : 1991)2023
Associations between thalamocortical functional connectivity and sensory over-responsivity in infants at high likelihood for ASD.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Functional brain connectivity from the fetal period through infancy: A narrative review of resting-state fMRI studies.Developmental cognitive neuroscience · 2026Review
- Alterations in Early Alpha-band Connectivity emerge in Infancy among children later diagnosed with Autism.medRxiv : the preprint server for health sciences · 2026Article
- A cascading effects model of early sensory development in autism.Psychological review · 2026Review
- Alterations in self-related brain networks in autism spectrum disorder: a systematic review of functional and structural magnetic resonance imaging studies.Psychoradiology · 2026Review
- Sensory abnormalities in autism spectrum disorder and their in vitro modeling.Translational psychiatry · 2025Review
- Brain functional connectivity correlates of autism diagnosis and familial liability in 24-month-olds.Journal of neurodevelopmental disorders · 2025Article
- Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism.Molecular autism · 2025Article
- Atypical Neural Responses to Native and Non-Native Language in Infants at High Likelihood for Developing Autism.Research square · 2024Article
- Identifying Diagnostic Biomarkers for Autism Spectrum Disorder From Higher-order Interactions Using the PED Algorithm.Neuroinformatics · 2024Article
- Functional connectivity in autism spectrum disorder evaluated using rs-fMRI and DKI.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Interoception in Autism: A Narrative Review of Behavioral and Neurobiological Data.Psychology research and behavior management · 2024Review
- Functional connectivity of the sensorimotor cerebellum in autism: associations with sensory over-responsivity.Frontiers in psychiatry · 2024Article
- Vasotocin receptor gene genotypes moderate the relationship between cortical thickness and sensory processing.Translational psychiatry · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Despite growing evidence implicating thalamic functional connectivity atypicalities in autism spectrum disorder (ASD), it remains unclear how such alterations emerge early in human development. Because the thalamus plays a critical role in sensory processing and neocortical organization early in life, its connectivity with other cortical regions could be key for studying the early onset of core ASD symptoms. Here, we investigated emerging thalamocortical functional connectivity in infants at high (HL) and typical (TL) familial likelihood for ASD in early and late infancy. We report significant thalamo-limbic hyperconnectivity in 1.5-month-old HL infants, and thalamo-cortical hypoconnectivity in prefrontal and motor regions in 9-month-old HL infants. Importantly, early sensory over-responsivity (SOR) symptoms in HL infants predicted a direct trade-off in thalamic connectivity whereby stronger thalamic connectivity with primary sensory regions and basal ganglia was inversely related to connectivity with higher order cortices. This trade-off suggests that ASD may be characterized by early differences in thalamic gating. The patterns reported here could directly underlie atypical sensory processing and attention to social vs. nonsocial stimuli observed in ASD. These findings lend support to a theoretical framework of ASD whereby early disruptions in sensorimotor processing and attentional biases early in life may cascade into core ASD symptomatology.
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