ArticleGeroScience2023
Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition.
Article in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2026Article
- From neighborhoods to brain health: an outreach model linking health literacy, cognitive care, research, and the arts, in San Francisco.Frontiers in public health · 2026Article
- Socio-environmental and health-related factors and their association with longitudinal change in brain neuroimaging markers through the plasma metabolome among UK adults: An additive Bayesian network analysis.Brain, behavior, & immunity - health · 2025Article
- Western Diet and Cognitive Decline: A Hungarian Perspective-Implications for the Design of the Semmelweis Study.Nutrients · 2025Review
- Cognitive variation reflects amyloid, tau, and neurodegenerative biomarkers in Alzheimer's disease.GeroScience · 2025Article
- Neighborhood disadvantage and the incidence of dementia in US Black women.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Association of neighborhood disadvantage with cognitive function and cortical disorganization in an unimpaired cohort: An exploratory study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Socioeconomic Disparities in Cognitive Impairment: The Role of Neighborhood Social Cohesion.Innovation in aging · 2025Article
- Article
- An epidemiological study of season of birth, mental health, and neuroimaging in the UK Biobank.PloS one · 2024Article
- Lifetime influences on imaging markers of adverse brain health and vascular disease.Cerebral circulation - cognition and behavior · 2024Article
- The interactive effects of psychosocial stress and diet composition on health in primates.Neuroscience and biobehavioral reviews · 2023Review
- Community Socioeconomic Disadvantage Relates to White Matter Hyperintensity Burden in Mid-to-Late Life Adults.Biopsychosocial science and medicineArticle
- Intersecting vulnerabilities: race, depression, and white matter hypointensity burden in aging.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing recognition that socioeconomic inequalities contribute to disparities in brain and cognitive health in older adults. However, whether neighborhood socioeconomic status (SES) buffers individuals with low individual SES against neurodegeneration, cerebrovascular disease, and poorer cognitive function is not well understood. Here, we evaluated whether neighborhood deprivation (Townsend deprivation index) interacted with individual SES (composite household income and education levels) on hippocampus volume, regional cortical thickness, white matter hyperintensities, and cognition in 19,638 individuals (mean age = 54.8) from the UK Biobank. We found that individuals with low individual SES had the smallest hippocampal volumes, greatest white matter hyperintensity burden, and poorest cognition if they were living in high deprivation neighborhoods but that these deleterious effects on brain and cognitive function were attenuated if they were living in low deprivation neighborhoods (p for interactions < .05). While neighborhood deprivation did not interact with individual SES to influence regional cortical thickness, higher neighborhood deprivation was independently associated with lower cortical thickness in 16 regions (false discovery rate q < .05). Across multiple brain indices and cognitive function analyses, we found converging evidence suggesting that low neighborhood deprivation may have a neuroprotective effect against neurodegeneration, cerebrovascular pathology, and cognitive impairment, particularly in vulnerable individuals with low household income and education levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.