Evidence map›Paper›PMID 37004506›Full record

ArticlePathobiology : journal of immunopathology, molecular and cellular biology2023

Senescent Tumor Cells Are Frequently Present at the Invasion Front: Implications for Improving Disease Control in Patients with Locally Advanced Prostate Cancer.

Sebastian Schwarz, Cathleen Nientiedt, Elena-Sophie Prigge, Adam Kaczorowski, Christine Geisler, Carlota Lucena Porcel, Magnus von Knebel Doeberitz, Markus Hohenfellner, Stefan Duensing

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathobiology : journal of immunopathology, molecular and cellular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sebastian SchwarzMolecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
Cathleen NientiedtMolecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
Elena-Sophie PriggeDepartment of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg and Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Adam KaczorowskiMolecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
Christine GeislerDepartment of Urology, University Hospital Heidelberg, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.
Carlota Lucena PorcelInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Magnus von Knebel DoeberitzDepartment of Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg and Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Markus HohenfellnerDepartment of Urology, University Hospital Heidelberg, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.
Stefan DuensingMolecular Urooncology, Department of Urology, University Hospital Heidelberg, Heidelberg, Germany.
Heidelberg University · DEGerman Cancer Research Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLocal tumor invasion is a critical factor for the outcome of men with prostate cancer. In particular, seminal vesicle invasion (SVI) has been reported to be associated with a more unfavorable prognosis. A better understanding of the functional state of invading prostate cancer cells is crucial to develop novel therapeutic strategies for patients with locally advanced disease.

methodsThe prognostic impact of local tumor progression was ascertained in over 1,000 men with prostate cancer. Prostate cancer specimens were stained by double-immunohistochemistry for the proliferation marker Ki-67 and the senescence marker p16INK4A. The migratory properties of senescent prostate cancer cells were analyzed in vitro using a wound healing assay and immunofluorescence microscopy for p16INK4A.

resultsWe confirm the notion that patients with SVI have a more unfavorable prognosis than patients with extraprostatic extension alone. Surprisingly, we found that the tumor invasion front frequently harbors p16INK4A-positive and Ki-67-negative, i.e., senescent, tumor cells. While the intraprostatic tumor periphery was a hotspot for both proliferation and expression of p16INK4A, the area of SVI showed less proliferative activity but was at the same time a hotspot of cells with increased nuclear p16INK4A expression. Senescence was associated with an accelerated migration of prostate cancer cells in vitro.

conclusionThis proof-of-concept study shows that invading prostate cancer cells frequently show signs of cellular senescence. This finding may open new avenues for neoadjuvant and adjuvant treatment concepts in men with locally advanced prostate cancer.

Indexed as

Prostatic NeoplasmsSeminal VesiclesHumansKi-67 AntigenMaleNeoplasm InvasivenessProstateProstatectomyKi-67 AntigenCellular senescencep16INK4AProstate cancerSeminal vesicle invasion

Identifiers

PMID37004506
PMCPMC10614482
OpenAlexW4362469016

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.