Evidence map›Paper›PMID 37004462›Full record

ArticleDrug and alcohol dependence2023

Decomposing risky decision-making in methamphetamine use disorder: Behavioral updating and D2 dopamine receptors.

Zoe Guttman, Mark Mandelkern, Dara G Ghahremani, Milky Kohno, Andy C Dean, Edythe D London

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Lower Striatal Dopamine D2 Receptor Availability in Individuals Who Test Positive for Quantitated Urine Metabolites of Tobacco and/or Marijuana Smoke.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Zoe GuttmanDepartment of Psychiatry and Biobehavioral Sciences and Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA.
Mark MandelkernVeterans Administration of Greater Los Angeles Health System, Los Angeles, CA 90073, USA; Department of Physics, University of California at Irvine, Irvine, CA 92697, USA.
Dara G GhahremaniDepartment of Psychiatry and Biobehavioral Sciences and Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA.
Milky KohnoDepartment of Psychiatry, Oregon Health & Science University, Oregon Health Sciences University, Portland, OR 97239, USA.
Andy C DeanDepartment of Psychiatry and Biobehavioral Sciences and Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA.
Edythe D LondonDepartment of Psychiatry and Biobehavioral Sciences and Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA; Veterans Administration of Greater Los Angeles Health System, Los Angeles, CA 90073, USA; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA 90024, USA; Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA. Electronic address: elondon@mednet.ucla.edu.
University of California, Los Angeles · USOregon Health & Science University · USUniversity of California, Irvine · USWest Los Angeles College · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
NEUROCHEMISTRY OF MODAFINIL-MA INTERACTION IN RAT BRAINP20DA022539 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2006 to 2009
$2.9M
Neural Systems, Inhibitory Control, and Methamphetamine DependenceR01DA020726 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2005 to 2008
$2.0M
Early Methamphetamine Abstinence: fMRI and CognitionR01DA015179 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE D · 2003 to 2005
$1.4M
Neurobehavioral Predictors of Cognitive Decline in Methamphetamine DependenceK23DA027734 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEAN, ANDREW CLARK · 2010 to 2014
$842k
CYP2D6, brain structure, and cognitive function in methamphetamine dependenceR21DA034928 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEAN, ANDREW CLARK · 2013 to 2014
$424k
Decision-Making with Negative Costs in Stimulant AbuseF31DA047110 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GUTTMAN, ZOE REBECCA · 2018 to 2020
$110k
Brain Function and Connectivity in Methamphetamine Dependence: The Link to Neuroinflammation and the Effects of IbudilastIK2CX001790 · VA · PORTLAND VA MEDICAL CENTER · PI KOHNO, MILKY · 2018 to 2024
–
CSRD VA IK2 CX001790NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NIDA NIH HHS F31 DA047110NIDA NIH HHS K23 DA027734NIDA NIH HHS P20 DA022539NIDA NIH HHS R01 DA015179NIDA NIH HHS R01 DA020726NIDA NIH HHS R21 DA034928NIDA NIH HHS T32 DA024635
6 · The paper itself

Abstract

backgroundEscalating misuse of amphetamine-type stimulants, mainly methamphetamine, has led to a staggering rise in associated overdose deaths and a pressing need to understand the basis of methamphetamine use disorder (MUD). MUD is characterized by disadvantageous decision-making, and people with MUD perform below controls on the Balloon Analogue Risk Task (BART), a laboratory test of decision-making under uncertainty. The BART presents a series of choices with progressively higher stakes-greater risk of loss and greater potential monetary reward. This research aimed to clarify whether impaired behavioral updating contributes to maladaptive performance on the BART.

methodsTwo groups (28 drug-abstinent participants with MUD and 16 healthy control participants) were compared on BART performance. Using a computational model, we deconstructed behavior into risk-taking and behavioral updating. A subset of participants (22 MUD, 15 healthy control) underwent [

resultsParticipants with MUD exhibited slower behavioral updating than the healthy controls (p = 0.0004, d=1.77). BPND in all four bilateral volumes of interest were higher in the healthy control group (ps < 0.005, ds < 2.16), and updating rate correlated positively with BPND in the caudate nucleus (p = 0.002), putamen (p = 0.002), and globus pallidus (p = 0.03).

conclusionsThe findings indicate that behavioral updating contributes to maladaptive decision-making in MUD and suggest that dysregulation of D2-type receptor signaling in the striatum and globus pallidus contributes to this behavioral deficit.

Indexed as

Amphetamine-Related DisordersCentral Nervous System StimulantsMethamphetamineCaudate NucleusCorpus StriatumHumansPositron-Emission TomographyReceptors, Dopamine D3Central Nervous System StimulantsMethamphetamineReceptors, Dopamine D3Computational psychiatryDecision-makingMethamphetamine use disorderRiskUncertainty

Identifiers

PMID37004462
PMCPMC10814877
OpenAlexW4361199795

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.