Evidence map›Paper›PMID 37003967›Full record

Observational studyBMC anesthesiology2023

Risk factors for delayed neurocognitive recovery in elderly patients undergoing thoracic surgery.

Lu Wang, Bin Chen, Tao Liu, Taijun Luo, Wanli Kang, Wei Liu

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07655687 (Intraoperative Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07655687 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Intraoperative Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery: a Multicenter Randomized Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2028Enrolled1,512ConditionsElderly Patients, Cancer Surgery, Hypothermia, Accidental, Targeted Temperature ManagementArmsTarget temperature management, Routine thermal management
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

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  4. Expression of Calcitonin Gene-related Peptide and Its Application to Cochlear Implantation Under Local Anesthesia With Monitored Anesthesia Care in the Very Elderly: The University of California, Los Angeles, Experience.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lu Wang *Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Bin Chen *Department of Anesthesiology, Beijing Chest Hospital, Capital Medical University, Beijing, China.
Tao LiuDepartment of Anesthesiology, Beijing Chest Hospital, Capital Medical University, Beijing, China.
Taijun LuoDepartment of Anesthesiology, Beijing Jishuitan Hospital, Beijing, China.
Wanli KangDepartment for disease prevention and control, Beijing Chest Hospital, Capital Medical University, Beijing, China.
Wei LiuDepartment of Anesthesiology, Beijing Chest Hospital, Capital Medical University, Beijing, China. WeiLiu9090@126.com.
Beijing Chest Hospital · CNBeijing Jishuitan Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the risk factors for delayed neurocognitive recovery in elderly patients undergoing thoracic surgery.

methodsA total of 215 elderly patients who underwent thoracic surgery between May 2022 and October 2022 were recruited in this prospective observational study. Cognitive function was tested by MoCA tests that were performed by the same trained physician before surgery, on postoperative day 4 (POD4), and on postoperative day 30 (POD30). Univariate and multivariate logistic regression models were used to analyze the risk factors for DNR.

resultsA total of 154 patients (55.8% men) with an average age of 67.99 ± 3.88 years were finally included. Patients had an average preoperative MoCA score of 24.68 ± 2.75. On the 30th day after surgery, 26 (16.88%) patients had delayed postoperative cognitive recovery, and 128 (83.12%) had postoperative cognitive function recovery. Diabetes mellitus (OR = 6.508 [2.049-20.664], P = 0.001), perioperative inadvertent hypothermia (< 35℃) (OR = 5.688 [1.693-19.109], P = 0.005), history of cerebrovascular events (OR = 10.211 [2.842-36.688], P < 0.001), and VICA (sevoflurane combined with propofol anesthesia) (OR = 5.306 [1.272-22.138], P = 0.022) resulted as independent risk factors of delayed neurocognitive recovery. On the POD4, DNR was found in 61 cases (39.6%), and age ≥ 70 years (OR = 2.311 [1.096-4.876], P = 0.028) and preoperative NLR ≥ 2.5 (OR = 0.428 [0.188-0.975], P = 0.043) were identified as independent risk factors.

conclusionsThe risk factors for delayed neurocognitive recovery in elderly patients undergoing thoracic surgery include diabetes, perioperative inadvertent hypothermia (< 35℃), VICA (sevoflurane combined with propofol anesthesia), and history of cerebrovascular events.

Indexed as

HypothermiaPropofolThoracic SurgeryAgedFemaleHumansMaleMiddle AgedPostoperative ComplicationsRisk FactorsSevofluranePropofolSevofluraneDelayed neurocognitive recoveryElderly patientsPerioperative neurocognitive disordersThoracic surgery

Identifiers

PMID37003967
PMCPMC10064736
OpenAlexW4362523708

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.