Evidence map›Paper›PMID 37003604›Full record

ArticleThe Journal of rheumatology2023

Myocarditis in Patients With Idiopathic Inflammatory Myopathies: Clinical Presentation and Outcomes.

Melody P Chung, Jana Lovell, William Kelly, Christopher A Mecoli, Jemima Albayda, Lisa Christopher-Stine, Nisha A Gilotra, Julie J Paik

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Melody P ChungM.P. Chung, MD, MS, W. Kelly, BS, C.A. Mecoli, MD, MHS, J. Albayda, MD, L. Christopher-Stine, MD, MPH, J.J. Paik, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; mchung25@jh.edu.ORCID 0000-0003-0221-4910
Jana LovellJ. Lovell, MD, N.A. Gilotra, MD, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
William KellyM.P. Chung, MD, MS, W. Kelly, BS, C.A. Mecoli, MD, MHS, J. Albayda, MD, L. Christopher-Stine, MD, MPH, J.J. Paik, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine.
Christopher A MecoliM.P. Chung, MD, MS, W. Kelly, BS, C.A. Mecoli, MD, MHS, J. Albayda, MD, L. Christopher-Stine, MD, MPH, J.J. Paik, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine.ORCID 0000-0002-1429-8392
Jemima AlbaydaM.P. Chung, MD, MS, W. Kelly, BS, C.A. Mecoli, MD, MHS, J. Albayda, MD, L. Christopher-Stine, MD, MPH, J.J. Paik, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine.ORCID 0000-0002-8030-9504
Lisa Christopher-StineM.P. Chung, MD, MS, W. Kelly, BS, C.A. Mecoli, MD, MHS, J. Albayda, MD, L. Christopher-Stine, MD, MPH, J.J. Paik, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine.ORCID 0000-0002-7150-7306
Nisha A GilotraJ. Lovell, MD, N.A. Gilotra, MD, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-4511-8008
Julie J PaikM.P. Chung, MD, MS, W. Kelly, BS, C.A. Mecoli, MD, MHS, J. Albayda, MD, L. Christopher-Stine, MD, MPH, J.J. Paik, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine.ORCID 0000-0001-8436-1601
Johns Hopkins University · US

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
Sample Processing and Immunoassay Research CoreP30AR070254 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CLIFTON O BINGHAM, Antony Rosen · 2016 to 2026
$8.9M
Skeletal Myopathy in Systemic Sclerosis: Devising a Classification Schema Predictive of OutcomesK23AR073927 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI PAIK, JULIE JISUN · 2020 to 2024
$787k
Optimizing the Approach to Identify Cancer-Associated MyositisK23AR075898 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI MECOLI, CHRISTOPHER · 2019 to 2023
$773k
NHLBI NIH HHS T32 HL007227NIAMS NIH HHS K23 AR073927NIAMS NIH HHS K23 AR075898NIAMS NIH HHS P30 AR070254
6 · The paper itself

Abstract

objectiveTo determine the clinical phenotype and outcomes of patients with idiopathic inflammatory myopathies (IIMs) and myocarditis.

methodsUsing the Johns Hopkins Myositis Center Research Registry, we identified 31 adult patients with IIM-out of a total of 3082 with confirmed or suspected muscle disease-with an encounter code of myocarditis from 2004 to 2021. Of these, 14 adult patients with IIM were adjudicated to have clinical myocarditis. Information about demographics, autoantibodies, and clinical outcomes was retrospectively collected and analyzed.

resultsOf 14 patients with IIM with clinical myocarditis, the median age at IIM diagnosis was 49 (IQR 35-56) years, and the median age at myocarditis diagnosis was 54 (IQR 36-61) years. The median duration between IIM diagnosis and myocarditis was 3 (IQR 2-9) years. The majority of patients were female (8/14, 57%) and Black (10/14, 71%). Antisynthetase syndrome was the most common IIM subtype (9/14, 64%). Anti-Jo1 (n = 4) and anti-PL12 (n = 3) were the most frequent autoantibodies. At myocarditis diagnosis, most patients (11/14, 79%) had active myositis, defined as elevated creatine kinase and/or muscle weakness; required hospitalization (13/14, 93%); and had reduced left ventricular ejection fraction (LVEF < 50%; 10/14, 71%). Despite intensification of immunosuppression, the 5-year overall survival rate from IIM diagnosis was 84%, and the 5-year overall survival rate from myocarditis diagnosis was 53%. Systolic dysfunction (LVEF < 40%) at final evaluation was observed in all expired patients (n = 6).

conclusionClinical presentations of myocarditis in this select cohort of patients with IIM were severe and heterogeneous with poor outcomes despite intensification of immunosuppression, potentially reflecting late detection of myocarditis.

Indexed as

MyocarditisMyositisAutoantibodiesFemaleHumansMaleRetrospective StudiesStroke VolumeVentricular Function, LeftAutoantibodiesantisynthetase syndromecardiacdermatomyositismyocarditismyositispolymyositis

Identifiers

PMID37003604
PMCPMC10523850
OpenAlexW4362450175

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.