Evidence map›Paper›PMID 37003581›Full record

ArticleExperimental eye research2023

Sigma 1 receptor activation improves retinal structure and function in the Rho

Shannon R Barwick, Haiyan Xiao, David Wolff, Jing Wang, Elizabeth Perry, Brendan Marshall, Sylvia B Smith

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shannon R BarwickDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA. Electronic address: sbarwick@augusta.edu.
Haiyan XiaoDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA.
David WolffDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Jing WangDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA.
Elizabeth PerryDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Brendan MarshallDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Sylvia B SmithDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA; James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, USA; Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Augusta University · US

Funding

Role of homocysteine in retinal diseaseR01EY012830 · NEI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI SMITH, SYLVIA B. · 2000 to 2016
$4.4M
Module 3: Gene Expression/ProteomicsP30EY031631 · NEI · AUGUSTA UNIVERSITY · PI Xingjun Fan · 2020 to 2026
$3.6M
Sigma 1 Receptor: a novel therapeutic target for retinal degenerationR01EY028103 · NEI · AUGUSTA UNIVERSITY · PI SMITH, SYLVIA B. · 2017 to 2019
$1.2M
NEI NIH HHS P30 EY031631NEI NIH HHS R01 EY012830NEI NIH HHS R01 EY028103
6 · The paper itself

Abstract

Retinitis pigmentosa (RP) is a group of devastating inherited retinal diseases that leads to visual impairment and oftentimes complete blindness. Currently no cure exists for RP thus research into prolonging vision is imperative. Sigma 1 receptor (Sig1R) is a promising small molecule target that has neuroprotective benefits in retinas of rapidly-degenerating mouse models. It is not clear whether Sig1R activation can provide similar neuroprotective benefits in more slowly-progressing RP models. Here, we examined Sig1R-mediated effects in the slowly-progressing Rho

Indexed as

Color VisionRetinal DegenerationRetinitis PigmentosaAnimalsDisease Models, AnimalElectroretinographyFemaleMaleMiceRetinaRhodopsinrho GTP-Binding ProteinsSigma-1 ReceptorRhodopsinrho GTP-Binding ProteinsSigma-1 Receptor(+)-pentazocinePhotoreceptor cellsRetinal degenerationRhodopsin P23HVisual acuity

Identifiers

PMID37003581
PMCPMC10155485
OpenAlexW4361267820

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.