ArticleOsteoarthritis and cartilage2023
Relation of pain sensitization to self-reported and performance-based measures of physical functioning: the Multicenter Osteoarthritis (MOST) study.
Article in Osteoarthritis and cartilage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Effects of Transcranial Direct Current Stimulation and Individualized Physical Therapy on Pain and Function in Individuals With Chronic Knee Pain: A Pilot Study.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Trial
- Predictors of Functional Recovery in Individuals Exposed to Late-Stage Exercise Programs After Total Knee Replacement: A Secondary Analysis of a Randomized Controlled Trial.Physical therapy · 2026Trial
- Safety and preliminary efficacy of transcutaneous auricular vagus nerve stimulation on chronic knee pain: A pilot trial.Osteoarthritis and cartilage open · 2025Trial
- Automated Kellgren-Lawrence grading of knee osteoarthritis using a multi-scale attention-based deep learning framework.Frontiers in medicine · 2026Article
- Longitudinal Trajectories of Pain Sensitization Over Nine Years in People With or at Risk of Knee Osteoarthritis.Arthritis care & research · 2026Article
- Relations of Social Determinants of Health to Pain and Function in Individuals with Knee Osteoarthritis in a Hispanic-dominant Community.Journal of racial and ethnic health disparities · 2025Article
- Association of Knee Pain Frequency and Severity with Quadriceps Strength but Not Rate of Decline Over Four Years.ACR open rheumatology · 2025Article
- Relation of pain sensitization to knee loading during walking in people with knee osteoarthritis.Osteoarthritis and cartilage · 2025Article
- Associations of pain sensitivity and conditioned pain modulation with physical activity: findings from the Multicenter Osteoarthritis Study (MOST).Osteoarthritis and cartilage · 2024Observational
- Associations between pain sensitization and measures of physical function in people with hand osteoarthritis: Results from the Nor-Hand study.Osteoarthritis and cartilage · 2023Article
- Quadriceps Strength, Postural Stability, and Pain Mediation in Bilateral Knee Osteoarthritis: A Comparative Analysis with Healthy Controls.Diagnostics (Basel, Switzerland) · 2023Article
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8 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveIt is unclear if alterations in nociceptive signaling contribute to poor physical functioning in persons with knee osteoarthritis (OA). We aimed to characterize the relation of pain sensitization to physical functioning in persons with or at risk for knee OA, and determine if knee pain severity mediates these relationships. MATERIALS AND
methodsWe used cross-sectional data from the Multicenter Osteoarthritis Study, a cohort study of persons with or at risk for knee OA. Pressure pain thresholds (PPTs) and temporal summation (TS) were assessed with quantitative sensory testing. Self-reported function was quantified with the Western Ontario and McMaster Universities Arthritis Index function subscale (WOMAC-F). Walking speed was determined during a 20-m walk. Knee extension strength was assessed with dynamometry. Relations of PPTs and TS to functional outcomes were examined with linear regression. The mediating role of knee pain severity was assessed with mediation analyses.
resultsAmong 1560 participants (60.5% female, mean age (SD) 67 (8), body mass index (BMI) 30.2 (5.5) kg/m
conclusionsHeightened pain sensitivity appears to be meaningfully associated with weaker knee extension in individuals with or at risk for knee OA. Relations to self-reported physical function and walking speed do not seem clinically meaningful. Knee pain severity differentially mediated these relationships.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.