Evidence map›Paper›PMID 37003056›Full record

ReviewSeminars in immunology2023

Immunoglobulins at the interface of the gut mycobiota and anti-fungal immunity.

Itai Doron, Takato Kusakabe, Iliyan D Iliev

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. A systems pharmacology-basedFrontiers in veterinary science · 2026
    Article
  8. Article
  9. Article
  10. Understanding the intricate interactions between microbiota and host.World journal of experimental medicine · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Itai DoronGastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY 10021, USA.
Takato KusakabeGastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY 10021, USA.
Iliyan D IlievGastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA; The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY 10021, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA. Electronic address: iliev@med.cornell.edu.
Weill Cornell Medicine · USCornell University · US

Funding

Commensal fungal communities in the regulation of immunity and intestinal inflammation.R01DK113136 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIYAN Dimitrov ILIEV · 2017 to 2026
$4.2M
Regulation and function of mucosal IgA immune responses to mycobiota in the gut.R01AI163007 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIEV, ILIYAN DIMITROV · 2021 to 2025
$2.9M
Mononuclear phagocyte networks in mycobiota regulation and antifungal immunity.R01DK121977 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ILIEV, ILIYAN DIMITROV · 2020 to 2024
$2.7M
NIAID NIH HHS R01 AI163007NIDDK NIH HHS R01 DK113136NIDDK NIH HHS R01 DK121977
6 · The paper itself

Abstract

The dynamic and complex community of microbes that colonizes the intestines is composed of bacteria, fungi, and viruses. At the mucosal surfaces, immunoglobulins play a key role in protection against bacterial and fungal pathogens, and their toxins. Secretory immunoglobulin A (sIgA) is the most abundantly produced antibody at the mucosal surfaces, while Immunoglobulin G (IgG) isotypes play a critical role in systemic protection. IgA and IgG antibodies with reactivity to commensal fungi play an important role in shaping the mycobiota and host antifungal immunity. In this article, we review the latest evidence that establishes a connection between commensal fungi and B cell-mediated antifungal immunity as an additional layer of protection against fungal infections and inflammation.

Indexed as

Antifungal AgentsImmunoglobulin A, SecretoryBacteriaHumansImmunity, MucosalImmunoglobulin GImmunoglobulinsAntifungal AgentsImmunoglobulin A, SecretoryImmunoglobulin GImmunoglobulinsAntifungal antibodiesB-cellsCandidaGerminal centersHumoral immunityHyphaeIgGMycobiomeSaccharomycesSecretory IgA

Identifiers

PMID37003056
PMCPMC10192079
OpenAlexW4361278648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.