ArticlePlant physiology2023
Plant extracellular self-DNA inhibits growth and induces immunity via the jasmonate signaling pathway.
Article in Plant physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Self-DNA acts as an immunostimulant for common bean (Phaseolus vulgaris) that induces defense against pests and diseases and increases seed yield.Crop health · 2026Article
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- Differential Immune Priming Effects of Banana Extracellular Self-DNA Derived from Bananas with Varying Disease Severities AgainstJournal of fungi (Basel, Switzerland) · 2026Article
- Extracellular ssDNA fromInternational journal of molecular sciences · 2026Article
- Extracellular DNA triggers glucosinolate-dependent defence responses against Frankliniella occidentalis.BMC plant biology · 2026Article
- DNA Aptamers Targeting BcSOD1: A Novel Strategy for Controlling Botrytis cinerea in Sustainable Agriculture.Plant biotechnology journal · 2025Article
- Pseudomonas sp. F204 Promoted Tomato Growth and Altered Rhizosphere Bacteria Community.Current microbiology · 2025Article
- Bioinformatics analysis and expression of the transcription factor MYC2 in Brassica napus in response to salt stress.Functional & integrative genomics · 2025Article
- Article
- Interplay Between ROS and Hormones in Plant Defense Against Pathogens.Plants (Basel, Switzerland) · 2025Review
- Purine-based infochemicals and immunometabolites: a comparative review of emerging signaling pathways in plants and animals.FEMS microbiology reviews · 2025Review
- Transcriptomics and Plant Hormone Analysis Reveal the Mechanism of Branching Angle Formation in Tea Plants (International journal of molecular sciences · 2025Article
- The Mitochondrial Blueprint: Unlocking Secondary Metabolite Production.Metabolites · 2024Review
- Extracellular DNA as a Strategy to Manage Vascular Wilt Caused byPlants (Basel, Switzerland) · 2024Article
- Xylem Sap Proteome Analysis Provides Insight into Root-Shoot Communication in Response to flg22.Plants (Basel, Switzerland) · 2024Article
- Extracellular Self- and Non-Self DNA Involved in Damage Recognition in the Mistletoe Parasitism of Mesquite Trees.International journal of molecular sciences · 2023Article
- Self-DNA Inhibition inBiology · 2023Article
- Jasmonate signaling drives defense responses against Alternaria alternata in chrysanthemum.BMC genomics · 2023Article
- Metabolic Responses of the MicroalgaInternational journal of molecular sciences · 2023Article
- The intrinsically disordered C-terminus of purinoceptor P2K1 fine-tunes plant responses to extracellular ATP.FEBS letters · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants have evolved sophisticated mechanisms to detect various forms of danger. Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged cells and activate the innate immunity. Recent evidence suggests that plant extracellular self-DNA (esDNA) can serve as a DAMP molecule. However, the mechanisms by which esDNA functions are largely unknown. In this study, we confirmed that esDNA inhibits root growth and triggers reactive oxygen species (ROS) production in a concentration- and species-specific manner in Arabidopsis (Arabidopsis thaliana) and tomato (Solanum lycopersicum L.). Furthermore, by combining RNA sequencing, hormone measurement, and genetic analysis, we found that esDNA-mediated growth inhibition and ROS production are achieved through the jasmonic acid (JA) signaling pathway. Specifically, esDNA induces JA production and the expression of JA-responsive genes. The esDNA-mediated growth inhibition, ROS production, and gene expression are impaired in the JA-related mutants. Finally, we found that the JA signaling pathway is required for the esDNA-elicited resistance against the pathogens Botrytis cinerea and Pseudomonas syringae pv. tomato DC3000. This finding highlights the importance of JA signaling in esDNA-mediated biological effects, thereby providing insight into how esDNA functions as a DAMP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.