Evidence map›Paper›PMID 37002814›Full record

ReviewNMR in biomedicine2023

Radiofrequency labeling strategies in chemical exchange saturation transfer MRI.

Chongxue Bie, Peter van Zijl, Jiadi Xu, Xiaolei Song, Nirbhay N Yadav

Abstract readReview
In one paragraph

Review in NMR in biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chongxue BieDepartment of Information Science and Technology, Northwest University, Xi'an, Shaanxi, China.
Peter van ZijlF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.
Jiadi XuF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.ORCID 0000-0001-9698-5622
Xiaolei SongCenter for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
Nirbhay N YadavF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.

Funding

WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Non-Invasive Imaging of Neurological Glycogen Storage DiseaseR01NS127280 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Nirbhay Narayan Yadav · 2022 to 2026
$2.1M
NIBIB NIH HHS P41 EB031771NICHD NIH HHS P50 HD103525NINDS NIH HHS R01 NS127280
6 · The paper itself

Abstract

Chemical exchange saturation transfer (CEST) MRI has generated great interest for molecular imaging applications because it can image low-concentration solute molecules in vivo with enhanced sensitivity. CEST effects are detected indirectly through a reduction in the bulk water signal after repeated perturbation of the solute proton magnetization using one or more radiofrequency (RF) irradiation pulses. The parameters used for these RF pulses-frequency offset, duration, shape, strength, phase, and interpulse spacing-determine molecular specificity and detection sensitivity, thus their judicious selection is critical for successful CEST MRI scans. This review article describes the effects of applying RF pulses on spin systems and compares conventional saturation-based RF labeling with more recent excitation-based approaches that provide spectral editing capabilities for selectively detecting molecules of interest and obtaining maximal contrast.

Indexed as

Image Interpretation, Computer-AssistedMagnetic Resonance ImagingAlgorithmsHydrogen-Ion ConcentrationProtonsRadio WavesProtonsCEST MRIexcitation-based labelingRF irradiation pulsesRF labelingsaturation-based labelingspectral editing

Identifiers

PMID37002814
PMCPMC10312378

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.