ArticleClinical oral investigations2023
Microbiological profile of root canals indicated for endodontic retreatment due to secondary endodontic infections or for prosthetic reasons.
Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Supplementary instrumentation did not enhance the removal of residual gutta-percha: a micro-computed tomography study.Odontology · 2026Article
- Laboratory investigation of intra-tooth variability in microbial communities from clinically isolated root canal and filling material.Clinical oral investigations · 2026Article
- Is apical periodontitis a matter of microbial diversity or time? A scoping review.Head & face medicine · 2026Article
- Article
- Correlation Between LPS and LTA Levels With Clinical Features in Secondary Endodontic Infections.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2025Article
- Effect of ultrasonic agitation of methylene blue during the antimicrobial photodynamic therapy in reducing viable cells from a multispecies biofilm and endotoxins: an in vitro study.Lasers in medical science · 2025Article
- A Biomimetic Approach to Diode Laser Use in Endodontic Treatment of Immature Teeth: Thermal, Structural, and Biological Analysis.Biomimetics (Basel, Switzerland) · 2025Article
- Antibacterial effect of femtosecond laser against Enterococcus faecalis and Fusobacterium nucleatum biofilms on dentin: an in vitro study.BMC oral health · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectiveThe objective of this study was to evaluate the microbiological profile of root canals indicated for endodontic retreatment due to secondary endodontic infections evidenced by the presence of chronic apical periodontitis (G1) or for prosthetic reasons, without clinical and radiographic signs of endodontic reinfection (G2).
methodsMicrobiological samples were collected from thirty teeth (N=30) out of which 15 were indicated for retreatment due to the presence of chronic apical periodontitis (G1) and 15 were indicated exclusively for prosthetic reasons (G2). Samples were collected from root canals before (S1), after chemomechanical preparation (S2), and after 30 days of intracanal medication composed of calcium hydroxide and 2% chlorhexidine gel (S3). The molecular analysis was performed using Nested-PCR for the detection of 17 bacterial species. The efficacy of each stage of the retreatment in reducing the microbial load was verified by counting colony-forming units (CFU). The statistical analysis considered a significance level of 5%.
resultsThe results showed that bacteria were detected in 100% of the cases in S1, in both groups, by Nested PCR. The most frequently found species in S1 in both groups were Enterococcus faecalis, Fusobacterium nucleatum, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Parvimonas micra. The microbial load of G1 was higher than G2 in the initial samples (S1). Endodontic retreatment was effective in reducing the microbial load in G1 and G2. Statistically significant associations were found between specific bacteria and clinical signs and symptoms.
conclusionIt was concluded that the microbial community present in the root canal of teeth indicated for endodontic retreatment is mixed and heterogeneous. G1 and G2 differ in the number of species per case and microbial load. CLINICAL RELEVANCE: Endodontic retreatment was effective in reducing the microbial load. Statistically significant associations were found between specific bacteria and clinical signs and symptoms.
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