ArticleCommunications biology2023
Bayesian stroke modeling details sex biases in the white matter substrates of aphasia.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Using unsupervised dimensionality reduction to identify lesion patterns predictive of post-stroke aphasia severity.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Partial least squares multimodal analysis of brain network correlates of language deficits in aphasia.Brain communications · 2025Article
- Bayesian modelling disentangles language versus executive control disruption in stroke.Brain communications · 2024Article
- Effects of Damage to the Integrity of the Left Dual-Stream Frontotemporal Network Mediated by the Arcuate Fasciculus and Uncinate Fasciculus on Acute/Subacute Post-Stroke Aphasia.Brain sciences · 2023Article
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Authors and funding
9 authors at 7 institutions in 4 countries.
Funding
Abstract
Ischemic cerebrovascular events often lead to aphasia. Previous work provided hints that such strokes may affect women and men in distinct ways. Women tend to suffer strokes with more disabling language impairment, even if the lesion size is comparable to men. In 1401 patients, we isolate data-led representations of anatomical lesion patterns and hand-tailor a Bayesian analytical solution to carefully model the degree of sex divergence in predicting language outcomes ~3 months after stroke. We locate lesion-outcome effects in the left-dominant language network that highlight the ventral pathway as a core lesion focus across different tests of language performance. We provide detailed evidence for sex-specific brain-behavior associations in the domain-general networks associated with cortico-subcortical pathways, with unique contributions of the fornix in women and cingular fiber bundles in men. Our collective findings suggest diverging white matter substrates in how stroke causes language deficits in women and men. Clinically acknowledging such sex disparities has the potential to improve personalized treatment for stroke patients worldwide.
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Registered trials
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