ArticleScientific reports2023
Genetic insights into the causal relationship between physical activity and cognitive functioning.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Apathy and Physical Activity: A Systematic Review and Meta-Analysis.Physiotherapy Canada. Physiotherapie Canada · 2026Pooled it
- Cognition, Depression, Pain, and Exercise Motives as Predictors of Longitudinal Profiles of Physical Activity During a Seven-Year Follow-Up Among Older Adults.Scandinavian journal of medicine & science in sports · 2024Trial
- Do Physical Exercises and Physical Activity Generate Positive Effects on Sleep Quality and Urinary Incontinence in Menopausal Women? A Systematic Review with Meta-Analysis.Journal of menopausal medicine · 2026Review
- Cognitive Trajectories and Subsequent Accelerometer-Measured Movement Behavior in Older Adults.JAMA network open · 2026Article
- Physical activity and sedentary behavior patterns in cognitive impairment: findings from a cross-sectional study in Punjab, North India.BMC public health · 2026Article
- Nonlinear Associations of Accelerometer-Based Sedentary Time With Cognitive Functions in the UK Biobank.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Longitudinal associations between self-reported exercise levels and cognition in ADAD.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Historic Cognitive Function Trajectories as Predictors of Sedentary Behavior and Physical Activity in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Temporal Interactions between Maintenance of Cerebral Cortex Thickness and Physical Activity from an Individual Person Micro-Longitudinal Perspective and Implications for Precision Medicine.Journal of personalized medicine · 2024Article
- Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study.Frontiers in aging neuroscience · 2024Article
- Physical exercise regulates microglia in health and disease.Frontiers in neuroscience · 2024Review
- Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction.Frontiers in molecular neuroscience · 2023Review
- Association between physical-activity trajectories and cognitive decline in adults 50 years of age or older.Epidemiology and psychiatric sciences · 2021Article
- Free-living physical activity and executive function: A multi-study analysis of age groups and times of day.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
9 authors.
Funding
Abstract
Physical activity and cognitive functioning are strongly intertwined. However, the causal relationships underlying this association are still unclear. Physical activity can enhance brain functions, but healthy cognition may also promote engagement in physical activity. Here, we assessed the bidirectional relationships between physical activity and general cognitive functioning using Latent Heritable Confounder Mendelian Randomization (LHC-MR). Association data were drawn from two large-scale genome-wide association studies (UK Biobank and COGENT) on accelerometer-measured moderate, vigorous, and average physical activity (N = 91,084) and cognitive functioning (N = 257,841). After Bonferroni correction, we observed significant LHC-MR associations suggesting that increased fraction of both moderate (b = 0.32, CI
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