ArticleScientific reports2023
Gene loss during a transition to multicellularity.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Genomic Exaptation and Regulatory Landscape Shifts as Key Mechanisms Enabling Flatworm Terrestrialization.Genome biology and evolution · 2026Article
- Translating Research on Evolutionary Transitions Into the Teaching of Hierarchical Complexity in University Biology Courses.Ecology and evolution · 2025Article
- Evolution of the Jawed Vertebrate (Gnathostomata) Stomach Through Gene Repertoire Loss: Findings from Agastric Species.Journal of developmental biology · 2025Article
- Illuminating the mystery of thylacine extinction: a role for relaxed selection and gene loss.Proceedings. Biological sciences · 2025Article
- Uncertainty minimization and pattern recognition inJournal of the Royal Society, Interface · 2025Article
- Article
- Functional analysis of regA paralog rlsD in Volvox carteri.The Plant journal : for cell and molecular biology · 2024Article
- Cell Type-Specific Promoters ofGenes · 2023Article
- Artificial intelligence vs. evolving super-complex tumor intelligence: critical viewpoints.Frontiers in artificial intelligence · 2023Article
- The Curious Case of Multicellularity in the Volvocine Algae.Frontiers in genetics · 2022Review
- Signatures of Transcription Factor Evolution and the Secondary Gain of Red Algae Complexity.Genes · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multicellular evolution is a major transition associated with momentous diversification of multiple lineages and increased developmental complexity. The volvocine algae comprise a valuable system for the study of this transition, as they span from unicellular to undifferentiated and differentiated multicellular morphologies despite their genomes being similar, suggesting multicellular evolution requires few genetic changes to undergo dramatic shifts in developmental complexity. Here, the evolutionary dynamics of six volvocine genomes were examined, where a gradual loss of genes was observed in parallel to the co-option of a few key genes. Protein complexes in the six species exhibited novel interactions, suggesting that gene loss could play a role in evolutionary novelty. This finding was supported by gene network modeling, where gene loss outpaces gene gain in generating novel stable network states. These results suggest gene loss, in addition to gene gain and co-option, may be important for the evolution developmental complexity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.