ArticleNPJ Regenerative medicine2023
3D bioprinting using a new photo-crosslinking method for muscle tissue restoration.
Article in NPJ Regenerative medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Hydrogels for Skeletal Muscle Regeneration: Design, Fabrication, and Future Applications.ACS polymers Au · 2026Review
- Epidermal Patch Technologies for Integrated Healthcare and Infection Management.Advanced healthcare materials · 2026Review
- Advances in 3D Bioprinting: Materials, Processes, and Emerging Applications.Micromachines · 2026Review
- Innovations in skin microphysiological systems for nonclinical testing and FDA modernization.Microsystems & nanoengineering · 2026Review
- Progressing Regenerative Medicine: Integrating Bioprinting Platforms for Stem Cell Applications.Stem cells international · 2026Review
- Converging Architectures: Precision Biomanufacturing and Soft Robotics Rewiring Tissue Engineering.Micromachines · 2025Article
- Advances and Challenges in 3D Bioprinted Cancer Models: Opportunities for Personalized Medicine and Tissue Engineering.Polymers · 2025Review
- Xolography for Biomedical Applications: Dual-Color Light-Sheet Printing of Hydrogels With Local Control Over Shape and Stiffness.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Bioprinting-By-Design of Hydrogel-Based Biomaterials for In Situ Skin Tissue Engineering.Gels (Basel, Switzerland) · 2025Review
- 3D bioprinting of fish skin-based gelatin methacryloyl (GelMA) bio-ink for use as a potential skin substitute.Scientific reports · 2024Article
- Recent advances and applications of artificial intelligence in 3D bioprinting.Biophysics reviews · 2024Review
- 3D printing tissue-engineered scaffolds for auricular reconstruction.Materials today. Bio · 2024Review
- Fabrication of fully aligned self-assembled cell-laden collagen filaments for tissue engineeringBioactive materials · 2024Article
- Engineered 3D liver-tissue model with minispheroids formed by a bioprinting process supported withBioactive materials · 2024Article
- Ultra-low content physio-chemically crosslinked gelatin hydrogel improves encapsulated 3D cell culture.International journal of biological macromolecules · 2024Article
- Embedded 3D bioprinting - An emerging strategy to fabricate biomimetic & large vascularized tissue constructs.Bioactive materials · 2024Review
- GelMA synthesis and sources comparison for 3D multimaterial bioprinting.Frontiers in bioengineering and biotechnology · 2024Article
- Recent advances in 3D bioprinted cartilage-mimicking constructs for applications in tissue engineering.Materials today. Bio · 2023Review
- Unlocking the Complexity of Neuromuscular Diseases: Insights from Human Pluripotent Stem Cell-Derived Neuromuscular Junctions.International journal of molecular sciences · 2023Review
- Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three-dimensional (3D) bioprinting is a highly effective technique for fabricating cell-loaded constructs in tissue engineering. However, the versatility of fabricating precise and complex cell-loaded hydrogels is limited owing to the poor crosslinking ability of cell-containing hydrogels. Herein, we propose an optic-fiber-assisted bioprinting (OAB) process to efficiently crosslink methacrylated hydrogels. By selecting appropriate processing conditions for the photo-crosslinking technique, we fabricated biofunctional cell-laden structures including methacrylated gelatin (Gelma), collagen, and decellularized extracellular matrix. To apply the method to skeletal muscle regeneration, cell-laden Gelma constructs were processed with a functional nozzle having a topographical cue and an OAB process that could induce a uniaxial alignment of C2C12 and human adipose stem cells (hASCs). Significantly higher degrees of cell alignment and myogenic activities in the cell-laden Gelma structure were observed compared with those in the cell construct that was printed using a conventional crosslinking method. Moreover, an in vivo regenerative potential was observed in volumetric muscle defects in a mouse model. The hASC-laden construct significantly induced greater muscle regeneration than the cell construct without topographical cues. Based on the results, the newly designed bioprinting process can prove to be highly effective in fabricating biofunctional cell-laden constructs for various tissue engineering applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.