ArticlePsychiatry research. Neuroimaging2023
Structural connectivity of an interoception network in schizophrenia.
Article in Psychiatry research. Neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- From Breath to Behavior: Respiratory Features Predict Visual Detection Performance.bioRxiv : the preprint server for biology · 2026Article
- A two-year longitudinal investigation of insula subregional cortical thickness and surface area in early psychosis.Schizophrenia research · 2025Article
- Diffusion Magnetic Resonance Imaging and Human Reward System Research: A Bibliometric Analysis and Visualisation of Current Research Trends.The Malaysian journal of medical sciences : MJMS · 2024Article
- Interoception in anxiety, depression, and psychosis: a review.EClinicalMedicine · 2024Review
- The insula: Leveraging cellular and systems-level research to better understand its roles in health and schizophrenia.Neuroscience and biobehavioral reviews · 2024Review
- The Interplay of Oxytocin and Attachment in Schizophrenic Patients: An fMRI Study.Brain sciences · 2023Article
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
Interoception refers to the processing, integration, and interpretation of bodily signals by the brain. Interoception is key to not only basic survival, but also motivational and affective functioning. There is emerging evidence suggesting altered interoception in schizophrenia, but few studies have explored potential neural underpinnings. The current study aims to investigate the anatomical connectivity of a previously identified interoception network in individuals with schizophrenia, and the relationship between network structural connectivity and both emotional functioning and clinical symptoms. Thirty-five participants with schizophrenia (SZ) and 36 healthy control participants (HC) underwent diffusion tensor imaging (DTI) and performed tasks measuring emotional functioning. Probabilistic tractography was used to identify white matter tracts connecting key hubs in an interoception network. Microstructural integrity of these tracts was compared across groups and correlated with measures of emotional functioning and symptom severity. Compared with HC, SZ exhibited altered structural connectivity in the interoception network. In HC, the structural connectivity of the network was significantly correlated with emotion recognition, supporting a link between the interoception network and emotional functioning. However, this correlation was much weaker in SZ. These findings suggest that altered interoception may have implications for illness mechanisms of schizophrenia, especially in relation to emotional deficits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.