Evidence map›Paper›PMID 37001144›Full record

ArticleJournal of the American Chemical Society2023

Investigating Native Metal Ion Binding Sites in Mammalian Histidine-Rich Glycoprotein.

Katrin Ackermann, Siavash Khazaipoul, Joshua L Wort, Amélie I S Sobczak, Hassane El Mkami, Alan J Stewart, Bela E Bode

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Genetic Markers of Postmortem Brain Iron.Journal of neurochemistry · 2025
    Article
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  9. EPR spectroscopic characterisation of native CuDalton transactions (Cambridge, England : 2003) · 2024
    Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Katrin AckermannEaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland.ORCID 0000-0003-1632-0503
Siavash KhazaipoulBiomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland.
Joshua L WortEaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland.
Amélie I S SobczakBiomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland.
Hassane El MkamiCentre of Magnetic Resonance, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland.
Alan J StewartBiomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland.ORCID 0000-0003-4580-1840
Bela E BodeEaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews KY16 9ST, Scotland.ORCID 0000-0002-3384-271X
University of St Andrews · GB

Funding

Biotechnology and Biological Sciences Research Council BB/R013780/1Biotechnology and Biological Sciences Research Council BB/T017740/1British Heart Foundation FS/15/42/31556British Heart Foundation PG/15/9/31270Wellcome TrustWellcome Trust 204821/Z/16/Z
6 · The paper itself

Abstract

Mammalian histidine-rich glycoprotein (HRG) is a highly versatile and abundant blood plasma glycoprotein with a diverse range of ligands that is involved in regulating many essential biological processes, including coagulation, cell adhesion, and angiogenesis. Despite its biomedical importance, structural information on the multi-domain protein is sparse, not least due to intrinsically disordered regions that elude high-resolution structural characterization. Binding of divalent metal ions, particularly Zn

Indexed as

Blood CoagulationGlycoproteinsAnimalsBinding SitesHistidine-Rich GlycoproteinMammalsGlycoproteinsHistidine-Rich Glycoprotein

Identifiers

PMID37001144
PMCPMC10103162
OpenAlexW4362460408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.