ArticleAnnals of clinical and translational neurology2023
Cholinergic basal forebrain atrophy in Parkinson's disease with freezing of gait.
Article in Annals of clinical and translational neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 11 citations in OpenAlex.
- Topography of Regional Cerebral GABAThe European journal of neuroscience · 2026Article
- Neurotransmitter Systems Underlying Freezing of Gait (FOG) in Parkinson's Disease.The European journal of neuroscience · 2026Review
- Asymmetric Cholinergic Basal Forebrain Atrophy Marks Freezing of Gait in Parkinson's Disease.The European journal of neuroscience · 2026Article
- Explainable SHAP- XGBoost with DAT and clinical data for freezing of gait detection in Parkinson disease.NPJ Parkinson's disease · 2026Article
- Microstructural alterations of parafascicular nucleus pathways associated with freezing of gait in Parkinson's disease.Brain communications · 2026Article
- Cortical gyrification deficits in early-stage Parkinson's disease: the importance of bradykinesia.Brain communications · 2026Article
- Oxysterol signaling in the central nervous system: cellular mechanisms and implications for neurodegeneration.Frontiers in molecular neuroscience · 2026Review
- Parkinson's disease mild cognitive impairment with MRI evidence of cholinergic nucleus 4 degeneration: A new subtype?Parkinsonism & related disorders · 2025Article
- Atrophy of ventral diencephalon is associated with freezing of gait in Parkinson's disease: analysis of two cohorts.NPJ Parkinson's disease · 2025Article
- Parkinson's Disease Mild Cognitive Impairment with MRI evidence of Cholinergic Nucleus 4 Degeneration: A New Subtype?Research square · 2024Article
- Effects of strategic white matter hyperintensities of cholinergic pathways on basal forebrain volume in patients with amyloid-negative neurocognitive disorders.Alzheimer's research & therapy · 2024Article
- Cholinergic nucleus degeneration and its association with gait impairment in Parkinson's disease.Journal of neuroengineering and rehabilitation · 2024Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMounting research support that cholinergic dysfunction plays a prominent role in freezing of gait (FOG), which commonly occurs in Parkinson's disease (PD). Basal forebrain (BF), especially the cholinergic nuclei 4 (Ch4), provides the primary source of the brain cholinergic input. However, whether the degeneration of BF and its innervated cortex contribute to the pathogenesis of FOG is unknown.
objectiveTo explore the role of structural alterations of BF and its innervated cortical brain regions in the pathogenesis of PD patients with freezing.
methodsMagnetic resonance imaging assessments and neurological assessments were performed on 20 PD patients with FOG (PD-FOG), 20 without FOG (PD-NFOG), and 21 healthy participants. Subregion volumes of the BF were compared among groups. Local gyrification index (LGI) was computed to reveal the cortical alternations. Relationships among subregional BF volumes, LGI, and the severity of FOG were evaluated by multiple linear regression.
resultsOur study discovered that, compared to PD-NFOG, PD-FOG exhibited significant Ch4 atrophy (p = 4.6 × 10
interpretationOur results imply that Ch4 degeneration and microstructural disorganization of its innervated cortical brain regions may play important roles in PD-FOG.
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