Evidence map›Paper›PMID 37000788›Full record

ArticlePloS one2023

Impact of sex in stroke in the young.

Anina Schwarzwald, Urs Fischer, David Seiffge, Morin Beyeler, Adrian Scutelnic, Johannes Kaesmacher, Pasquale Mordasini, Tomas Dobrocky, Jan Gralla, Mirjam R Heldner and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Anina SchwarzwaldDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.ORCID 0000-0002-2541-3886
Urs FischerDepartment of Neurology, Universitätsspital, Basel University Hospital, and University of Basel, Basel, Switzerland.
David SeiffgeDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Morin BeyelerDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.ORCID 0000-0001-5911-7957
Adrian ScutelnicDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Johannes KaesmacherUniversity Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Pasquale MordasiniInstitute of Diagnostic and Interventional Neuroradiology, Cantonal Hospital, St. Gallen, Guangdong Province, China.
Tomas DobrockyUniversity Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Jan GrallaUniversity Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Mirjam R HeldnerDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Roza UmarovaDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Thomas R MeinelDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Marcel ArnoldDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Simon JungDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Barbara Goeggel SimonettiDepartment of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
University of Bern · CHUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeLimited data is available on sex differences in young stroke patients describing discrepant findings. This study aims to investigate the sex differences in young stroke patients.

methodsProspective cohort study comparing risk factors, etiology, stroke localization, severity on admission, management and outcome in patients aged 16-55 years with acute ischemic stroke consecutively included in the Bernese stroke database between 01/2015 to 12/2018 with subgroup analyses for very young (16-35y) and young patients (36-55y).

results689 patients (39% female) were included. Stroke in women dominated in the very young (53.8%, p<0.001) and in men in the young (63.9%, p<0.001). As risk factors only sleep-disordered breathing was more predominant in men in the very young, whereas arterial hypertension, diabetes and atrial fibrillation did not differ in women and men older than 35y. The higher frequency of stroke in women in the very young may be explained by the sex specific risk factors such as pregnancy, puerperium, the use of oral contraceptives, and hormonal replacement therapy. Stroke severity at presentation, etiology, stroke localization, management, and outcome did not differ between women and men.

conclusionsThe main finding of this study is that sex specific risk factors in women may contribute to a large extent to the higher incidence of stroke in the very young in women. Important modifiable stroke risk factors, such as arterial hypertension, diabetes mellitus and atrial fibrillation did not differ in women and men, either in the young as well as in the very young. These findings have major implications for primary preventive strategies of stroke in young people.

Indexed as

Atrial FibrillationDiabetes MellitusHypertensionIschemic StrokeStrokeAdolescentFemaleHumansMaleProspective StudiesRisk FactorsSex Factors

Identifiers

PMID37000788
PMCPMC10065293
OpenAlexW4362475386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.