Evidence map›Paper›PMID 37000412›Full record

ArticleAngewandte Chemie (International ed. in English)2023

Ruthenium-Catalyzed C-C Coupling of Terminal Alkynes with Primary Alcohols or Aldehydes: α,β-Acetylenic Ketones (Ynones) via Oxidative Alkynylation.

Eliezer Ortiz, Madeline M Evarts, Zachary H Strong, Jonathan Z Shezaf, Michael J Krische

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eliezer OrtizUniversity of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX 78712-1167, USA.
Madeline M EvartsUniversity of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX 78712-1167, USA.
Zachary H StrongUniversity of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX 78712-1167, USA.
Jonathan Z ShezafUniversity of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX 78712-1167, USA.
Michael J KrischeUniversity of Texas at Austin, Department of Chemistry, 105 E 24th St. (A5300), Austin, TX 78712-1167, USA.ORCID http://orcid.org/0000-0001-8418-9709

Funding

Substituted Piperidine Formation via C-C Bond Forming Transfer HydrogenationR01GM069445 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI KRISCHE, MICHAEL J · 2005 to 2024
$6.7M
NIGMS NIH HHS R01 GM069445NIGMS NIH HHS RO1-GM069445
6 · The paper itself

Abstract

The first metal-catalyzed oxidative alkynylations of primary alcohols or aldehydes to form α,β-acetylenic ketones (ynones) are described. Deuterium labelling studies corroborate a novel reaction mechanism in which alkyne hydroruthenation forms a transient vinylruthenium complex that deprotonates the terminal alkyne to form the active alkynylruthenium nucleophile.

Indexed as

AlcoholAlkyneHydrogen TransferRutheniumYnone

Identifiers

PMID37000412
PMCPMC10213147

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.