Evidence map›Paper›PMID 37000344›Full record

ArticleJournal of assisted reproduction and genetics2023

Elevated body mass index in modified natural cycle frozen euploid embryo transfers is not associated with live birth rate.

Isabel Beshar, Amin A Milki, Rebecca M Gardner, Wendy Y Zhang, Jasmyn K Johal, Brindha Bavan

Open access · greenAbstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Isabel BesharDepartment of Obstetrics & Gynecology, Stanford Hospital, Center for Academic Medicine, MC 5317, 453 Quarry Road, Palo Alto, CA, 94304, USA. ibeshar@stanford.edu.ORCID http://orcid.org/0000-0002-4367-836X
Amin A MilkiDivision of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Stanford University, 1195 W Fremont Avenue, Sunnyvale, CA, 94087, USA.
Rebecca M GardnerDepartment of Epidemiology & Population Health, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Wendy Y ZhangDepartment of Obstetrics & Gynecology, Stanford Hospital, Center for Academic Medicine, MC 5317, 453 Quarry Road, Palo Alto, CA, 94304, USA.
Jasmyn K JohalRonald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 1305 York Avenue, 6th Floor, New York, NY, 10021, USA.
Brindha BavanDivision of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Stanford University, 1195 W Fremont Avenue, Sunnyvale, CA, 94087, USA.
Stanford University · USCornell University · USStanford Health Care · US

Funding

Stanford BSSR Pre-Doctoral Training Program at the Intersection of Data Sciences with Behavioral, Social, and Population Health ResearchT32HL151323 · NHLBI · STANFORD UNIVERSITY · PI Michelle Christina Odden, David H Rehkopf · 2020 to 2026
$1.6M
NHLBI NIH HHS T32 HL151323
6 · The paper itself

Abstract

purposeTo assess the impact of elevated BMI on the success of modified natural cycle frozen embryo transfers (mNC-FET) of euploid embryos.

methodsThis retrospective cohort study at a single academic institution reviewed mNC-FET involving single euploid blastocysts from 2016 to 2020. Comparison groups were divided by pre-pregnancy BMI (kg/m

results562 mNC-FET cycles were completed in 425 patients over the study period. Overall, there were 316 transfers performed in normal weight patients, 165 in overweight patients, and 81 in obese weight patients. There was no statistically significant difference in LBR across all BMI categories (55.4% normal weight, 61.2% overweight, and 64.2% obese). There was also no difference for the secondary outcome, CPR, across all categories (58.5%, 65.5%, and 66.7%, respectively). This was confirmed in GEE analysis when adjusting for confounders.

conclusionWhile increased weight has commonly been implicated in poor pregnancy outcomes, the effect of BMI on the success of mNC-FET remains debated. Across five years of data from a single institution using euploid embryos in mNC-FET cycles, elevated BMI was not associated with reduced LBR or CPR.

Indexed as

Birth RateOverweightBody Mass IndexCryopreservationEmbryo TransferFemaleHumansLive BirthObesityPregnancyPregnancy RateRetrospective StudiesBMIClinical pregnancyEmbryo transferLive birth rateObesityOverweight

Identifiers

PMID37000344
PMCPMC10239415
OpenAlexW4362458015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.