SynthesisEuropean archives of psychiatry and clinical neuroscience2024
A multimodal meta-analysis of regional functional and structural brain abnormalities in obsessive-compulsive disorder.
Synthesis in European archives of psychiatry and clinical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Alterations in resting-state brain activity patterns following antidepressant treatment: insights from a coordinate-based meta-analysis.Psychological medicine · 2025Pooled it
- Grey matter volume differences in pediatric obsessive-compulsive disorder: a meta-analysis of voxel-based morphometry studies.BMC psychiatry · 2025Pooled it
- Regional Cerebellar Volumetrics in Obsessive-Compulsive Disorder: An ENIGMA-OCD Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- A Gut-Brain Axis Underlying Succinate-Associated Compulsive-Like Behavior.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Distinct structural abnormalities in obsessive-compulsive and alcohol use disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Mechanisms of Selective Serotonin Reuptake Inhibitors in Treatment-Resistant Obsessive-Compulsive Disorder: Cortico-Striatal Circuitry, Glutamatergic Dysregulation, and Neuroplastic Constraints.Molecular neurobiology · 2026Review
- Repetitive transcranial magnetic stimulation treatment for obsessive-compulsive disorder.Current opinion in psychiatry · 2026Review
- Sensorimotor circuit connectivity as a candidate biomarker for responsiveness to sertraline in obsessive-compulsive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- "It Doesn't Matter Where OCD Comes From," or Does It?Current psychiatry reports · 2026Review
- Efficacy of Dextromethorphan Augmentation in SSRI-Resistant Obsessive-Compulsive Disorder: A Randomized Controlled Trial.Health science reports · 2026Article
- Global scientific trends on neuroimaging in obsessive-compulsive disorder in the early twenty-first century: a bibliometric analysis and visualization analysis.Annals of general psychiatry · 2026Review
- Theta-Alpha Dysregulation reveals impaired endogenous cognitive control in adolescent Obsessive-Compulsive disorder.NeuroImage. Clinical · 2026Article
- Differences in cortical gyrification and fractional amplitude of low-frequency fluctuations between early- and late-onset obsessive-compulsive disorder.Journal of psychiatry & neuroscience : JPN · 2026Article
- Unveiling anomalies in visual processing regions in obsessive-compulsive disorder: evidence from gray matter volume and functional connectivity analyses.Brain imaging and behavior · 2025Article
- Neuroimaging and Machine Learning in OCD: Advances in Diagnostic and Therapeutic Insights.Brain sciences · 2025Review
- Decoding the striatum of drug-naive patients with obsessive-compulsive disorder: a transcriptome and longitudinal functional magnetic resonance imaging study.Translational psychiatry · 2025Article
- Normative Modeling of Thalamic Nuclear Volumes and Characterization of Lateralized Volume Alterations in Alzheimer's Disease Versus Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Changes in the medial prefrontal cortex metabolites after 6 months of medication therapy for patients with bipolar disorder: ACNS neuroscience & therapeutics · 2024Article
- From compulsivity to compulsion: the neural basis of compulsive disorders.Nature reviews. Neuroscience · 2024Review
- Normative modeling of thalamic nuclear volumes.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous neuroimaging studies of resting-state functional imaging and voxel-based morphometry (VBM) have revealed abnormalities in specific brain regions in obsessive-compulsive disorder (OCD), but results have been inconsistent. We conducted a whole-brain voxel-wise meta-analysis on resting-state functional imaging and VBM studies that investigated differences of functional activity and gray matter volume (GMV) between patients with OCD and healthy controls (HCs) using seed-based d mapping (SDM) software. A total of 41 independent studies (51 datasets) for resting-state functional imaging and 42 studies (46 datasets) for VBM were included by a systematic literature search. Overall, patients with OCD displayed increased spontaneous functional activity in the bilateral inferior frontal gyrus (IFG) (extending to the bilateral insula) and bilateral medial prefrontal cortex/anterior cingulate cortex (mPFC/ACC), as well as decreased spontaneous functional activity in the bilateral paracentral lobule, bilateral cerebellum, left caudate nucleus, left inferior parietal gyri, and right precuneus cortex. For the VBM meta-analysis, patients with OCD displayed increased GMV in the bilateral thalamus (extending to the bilateral cerebellum), right striatum, and decreased GMV in the bilateral mPFC/ACC and left IFG (extending to the left insula). The conjunction analyses found that the bilateral mPFC/ACC, left IFG (extending to the left insula) showed decreased GMV with increased intrinsic function in OCD patients compared to HCs. This meta-analysis demonstrated that OCD exhibits abnormalities in both function and structure in the bilateral mPFC/ACC, insula, and IFG. A few regions exhibited only functional or only structural abnormalities in OCD, such as the default mode network, striatum, sensorimotor areas, and cerebellum. It may provide useful insights for understanding the underlying pathophysiology of OCD and developing more targeted and efficacious treatment and intervention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.