Evidence map›Paper›PMID 36999646›Full record

ArticleGenesis (New York, N.Y. : 2000)2023

Characterizing expression pattern of Six2Cre during mouse craniofacial development.

Meenakshi Umar, Chunmin Dong, Fenglei He

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genesis (New York, N.Y. : 2000), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Meenakshi UmarDepartment of Cell and Molecular Biology, School of Science and Engineering, Tulane University, New Orleans, Louisiana, USA.ORCID 0000-0002-8454-2274
Chunmin DongDepartment of Cell and Molecular Biology, School of Science and Engineering, Tulane University, New Orleans, Louisiana, USA.
Fenglei HeDepartment of Cell and Molecular Biology, School of Science and Engineering, Tulane University, New Orleans, Louisiana, USA.ORCID 0000-0003-4717-8001
Tulane University · US

Funding

Molecular mechanisms of tissue interactions during coronal suture developmentR01DE028918 · NIDCR · TULANE UNIVERSITY OF LOUISIANA · PI HE, FENGLEI · 2019 to 2023
$1.8M
NIDCR NIH HHS R01 DE028918
6 · The paper itself

Abstract

Craniofacial development is a complex process involving diverse cell populations. Various transgenic Cre lines have been developed to facilitate studying gene function in specific tissues. In this study, we have characterized the expression pattern of Six2Cre mice at multiple stages during craniofacial development. Our data revealed that Six2Cre lineage cells are predominantly present in frontal bone, mandible, and secondary palate. Using immunostaining method, we found that Six2Cre triggered reporter is co-expressed with Runx2. In summary, our data showed Six2Cre can be used to study gene function during palate development and osteogenesis in mouse models.

Indexed as

MandibleOsteogenesisAnimalsMiceMice, Transgeniccraniofacial developmentlineage tracingmouseosteogenesispalate

Identifiers

PMID36999646
PMCPMC10527692
OpenAlexW4362458553

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.