Evidence map›Paper›PMID 36999472›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2023

Research progress in effects of pyroptosis on intestinal inflammatory injury.

Dandan Liu, Xiaolin Zhong, Wenyu Cao, Ling Chen

Open access · greenAbstract read
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Mitochondrial Quality Control and Cell Death.International journal of molecular sciences · 2025
    Review
  2. Pyroptosis and sepsis-associated acute kidney injury.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dandan LiuDepartment of Endocrinology and Metabolism, First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang Hunan 421001. 714036750@qq.com.
Xiaolin ZhongDepartment of Endocrinology and Metabolism, First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang Hunan 421001.
Wenyu CaoClinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang Hunan 421001, China.
Ling ChenDepartment of Endocrinology and Metabolism, First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang Hunan 421001. lingchen-cl@outlook.com.
First Affiliated Hospital of University of South China · CNUniversity of South China · CN

Funding

the National Natural Science Foundation 82100537the Project of Health Comission of Hunan Province 202110002229
6 · The paper itself

Abstract

Inflammatory injury of the intestine is often accompanied by symptoms such as damage to intestinal mucosa, increased intestinal permeability, and intestinal motility dysfunction. Inflammatory factors spread throughout the body via blood circulation, and can cause multi-organ failure. Pyroptosis is a newly discovered way of programmed cell death, which is mainly characterized by the formation of plasma membrane vesicles, cell swelling until the rupture of the cell membrane, and the release of cell contents, thereby activating a drastic inflammatory response and expanding the inflammatory response cascade. Pyroptosis is widely involved in the occurrence of diseases, and the underlying mechanisms for inflammation are still a hot spot of current research. The caspase-1 mediated canonical inflammasome pathway of pyroptosis and caspase-4/5/8/11-mediated non-canonical inflammasome pathway are closely related to the occurrence and development of intestinal inflammation. Therefore, investigation of the signaling pathways and molecular mechanisms of pyroptosis in intestinal injury in sepsis, inflammatory bowel diseases, infectious enteristic, and intestinal tumor is of great significance for the prevention and treatment of intestinal inflammatory injury.

Indexed as

InflammasomesPyroptosisApoptosisCaspase 1HumansInflammationCaspase 1Inflammasomesinfectious enteritisinflammationinflammatory bowel diseasesintestinal inflammatory injuryintestinal tumorpyroptosissepsis

Identifiers

PMID36999472
PMCPMC10930348
OpenAlexW4362507497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.