Evidence map›Paper›PMID 36999281›Full record

ReviewWomen's health (London, England)

Overview of ectopic pregnancy diagnosis, management, and innovation.

Kellie Mullany, Madeline Minneci, Ryan Monjazeb, Olivia C Coiado

Registry-linked trialAbstract readReview
In one paragraph

Review in Women's health (London, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07431411 (The Effect of Reproductive Health Education on Contraceptive Method Use Intention and Sexual Life Quality of Women Diagnosed With Ectopic Pregnancy), which is not on this map. Cited by 100 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07431411 nanot yet recruitingnot on this map

The Effect of Reproductive Health Education on Contraceptive Method Use Intention and Sexual Life Quality of Women Diagnosed With Ectopic Pregnancy

TypeinterventionalSponsorBuket KömürcüRan2026 to 2026Enrolled102ConditionsEctopic PregnancyArmsReproductive Health Counseling and Educational Brochure
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Timing of conception after methotrexate and subsequent pregnancy outcomes: A retrospective cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Primary splenic pregnancy: a case report.Journal of medical case reports · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Multiple Regression Analysis of Ultrasound and Clinical Features for Quantitative Evaluation of Tubal Pregnancy Rupture.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
    Review
  18. Article
  19. Article
  20. Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kellie MullanyCarle Illinois College of Medicine, University of Illinois Urbana Champaign, Urbana, IL, USA.ORCID 0000-0002-6806-1032
Madeline MinneciCarle Illinois College of Medicine, University of Illinois Urbana Champaign, Urbana, IL, USA.ORCID 0000-0003-0983-1022
Ryan MonjazebCarle Illinois College of Medicine, University of Illinois Urbana Champaign, Urbana, IL, USA.ORCID 0000-0001-9558-1909
Olivia C CoiadoDepartment of Biomedical and Translational Sciences, Carle Illinois College of Medicine and Department of Bioengineering, University of Illinois Urbana Champaign, Urbana, IL, USA.ORCID 0000-0003-1322-5877

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ectopic pregnancies are the leading cause of maternal mortality in the first trimester, with an incidence of 5%-10% of all pregnancy-related deaths. Diagnosis of ectopic pregnancies is difficult due to clinical mimics and non-specific symptoms of abdominal pain and vaginal bleeding. The current standard for ectopic pregnancy diagnosis includes ultrasound imaging and β-human chorionic gonadotropin (β-hCG) monitoring. In addition to β-hCG, serum markers are being explored as a potential for diagnosis, with activin-AB and pregnancy-associated plasma protein A specifically showing promise. Other diagnostic methods include endometrial sampling, with dilation and curettage showing the highest specificity; however, frozen section reduces the diagnostic timeline which may improve outcomes. Treatment options for confirmed ectopic pregnancies include medical, surgical, and expectant management. Chosen treatment methodology is based on β-hCG levels, hematologic stability, and risk of ectopic pregnancy rupture. Current innovations in ectopic pregnancy management aim to preserve fertility and include laparoscopic partial tubal resection with end-to-end anastomosis and uterine artery embolization with intrauterine infusion of methotrexate. Psychological interventions to improve patient mental health surrounding ectopic pregnancy diagnosis and treatment are also valuable innovations. This literature review aims to bring light to current ectopic pregnancy diagnostics, treatments, and future directions.

Indexed as

LaparoscopyPregnancy, EctopicChorionic Gonadotropin, beta Subunit, HumanFemaleHumansMethotrexatePregnancyUltrasonographyChorionic Gonadotropin, beta Subunit, HumanMethotrexateectopic pregnancyectopic pregnancy diagnosisectopic pregnancy innovationectopic pregnancy treatmentglobal women’s healthmaternal healthpublic healthreproductive healthRoe v. Wadewomen’s health

Identifiers

PMID36999281
PMCPMC10071153

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.