Evidence map›Paper›PMID 36999133›Full record

ArticleIn silico pharmacology2023

Target-specificity of different amyrin subunits in impeding HCV influx mechanism inside the human cells considering the quantum tunnel profiles and molecular strings of the CD81 receptor: a combined in silico and in vivo study.

Anika Jabin, Mohammad Fahim Uddin, Salauddin Al Azad, Ashfaque Rahman, Fawzia Tabassum, Pritthy Sarker, A K M Helal Morshed, Samiur Rahman, Fatima Fairuz Raisa, Musfiqur Rahman Sakib and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In silico pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 27 citations in OpenAlex.

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  6. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 4 countries.

Anika JabinDepartment of Biochemistry and Microbiology, North South University, Dhaka, 1229 Bangladesh.
Mohammad Fahim UddinCollege of Material Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018 Zhejiang People's Republic of China.
Salauddin Al AzadKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122 Jiangsu Province People's Republic of China.ORCID 0000-0002-3035-7882
Ashfaque RahmanDepartment of Biochemistry and Microbiology, North South University, Dhaka, 1229 Bangladesh.
Fawzia TabassumDepartment of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Sylhet, 3114 Bangladesh.
Pritthy SarkerDepartment of Biochemistry and Microbiology, North South University, Dhaka, 1229 Bangladesh.
A K M Helal MorshedPathology and Pathophysiology Major, Academy of Medical Science, Zhengzhou University, Zhengzhou City, 450001 Henan Province People's Republic of China.
Samiur RahmanDepartment of Biochemistry and Microbiology, North South University, Dhaka, 1229 Bangladesh.
Fatima Fairuz RaisaDepartment of Electrical and Electronic Engineering, Brac University, Dhaka, 1212 Bangladesh.
Musfiqur Rahman SakibDepartment of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100 Bangladesh.
Abeer Hasan OliveDepartment of Pharmacy, East West University, Dhaka, 1212 Bangladesh.
Tabassum IslamDepartment of Computer Science and Engineering, East West University, Dhaka, 1212 Bangladesh.
Ramisha TahsinDepartment of Pharmaceutical Sciences, North South University, Dhaka, 1229 Bangladesh.
Shahlaa Zernaz AhmedDepartment of Biochemistry and Microbiology, North South University, Dhaka, 1229 Bangladesh.
Partha BiswasDepartment of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore, 7408 Bangladesh.
Mst Umme HabibaData Science Research Unit, RPG Interface Lab, Jashore, 7400 Bangladesh.
Mahbuba SiddiquyState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122 Jiangsu Province People's Republic of China.
Maryam JafaryDivision of Food Safety and Hygiene, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, 1416634793 Iran.
North South University · BDEast West University · BDJiangnan University · CNBRAC University · BDGopalganj Science and Technology University · BDInterface (United States) · USShahjalal University of Science and Technology · BDTehran University of Medical Sciences · IRZhejiang Sci-Tech University · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HCV is a hepatotropic RNA virus recognized for its frequent virulence and fatality worldwide. Despite many vaccine development programs underway, researchers are on a quest for natural bioactive compounds due to their multivalent efficiencies against viral infections, considering which the current research aimed to figure out the target-specificity and therapeutic potentiality of α, β, and δ subunits of amyrin, as novel bioactive components against the HCV influx mechanism. Initially, the novelty of amyrin subunits was conducted from 203 pharmacophores, comparing their in-silico pharmacokinetic and pharmacodynamic profiles. Besides, the best active site of CD81 was determined following the quantum tunneling algorithm. The molecular dynamic simulation was conducted (100 ns) following the molecular docking steps to reveal the parameters- RMSD (Å); Cα; RMSF (Å); MolSA (Å

Indexed as

CD81 receptorCo-expressed genes behind HCV invasionDMN-induced hepatic fibrosisHCV infectionIn-silico pharmacokinetics and pharmacodynamicsTarget-specificity of amyrins

Identifiers

PMID36999133
PMCPMC10052254
OpenAlexW4361297015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.