Evidence map›Paper›PMID 36999036›Full record

ArticleFrontiers in immunology2023

Cyclophosphamide-induced seizures in a patient with neuropsychiatric systemic lupus erythematosus (NPSLE): A case report.

Lingshu Zhang, Ying Shi, Jingyao Zhang, Jing Wu, Wei Jiang

Open access · goldFull text readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Lingshu ZhangDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.
Ying ShiDepartment of Integrated Traditional Chinese and Western Medicine, The Ninth People's Hospital of Chongqing, Chongqing, China.
Jingyao ZhangCore Facilities of West China Hospital, Sichuan University, Chengdu, China.
Jing WuInternal Medicine Department, Xihua University Hospital, Chengdu, China.
Wei JiangDepartment of Integrated Traditional Chinese and Western Medicine, The Ninth People's Hospital of Chongqing, Chongqing, China.
First People's Hospital of Chongqing · CNSichuan University · CNXihua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seizures are life-threatening complications of neuropsychiatric systemic lupus erythematosus (NPSLE) and are often associated with poor outcomes. Cyclophosphamide immunotherapy is the mainstay of NPSLE treatment. We report the unique case of a patient with NPSLE who developed seizures soon after her first and second doses of low-dose cyclophosphamide. The exact pathophysiological mechanism underlying cyclophosphamide-induced seizures is not well understood. However, this unusual drug-associated side effect of cyclophosphamide is thought to be due to the drug's unique pharmacology. Clinicians should be aware of this complication to make a correct diagnosis and adjust the immunosuppressive regimens very carefully.

Indexed as

Lupus Erythematosus, SystemicLupus Vasculitis, Central Nervous SystemCyclophosphamideFemaleHumansImmunosuppressive AgentsSeizuresCyclophosphamideImmunosuppressive Agentscyclophosphamideimmunotherapyneuropsychiatric lupus erythematosusseizureside effect analysis

Identifiers

PMID36999036
PMCPMC10049787
OpenAlexW4324134112

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read26
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.