Evidence map›Paper›PMID 36998705›Full record

ArticleEXCLI journal2023

Mixture effects of co-formulants and two plant protection products in a liver cell line.

Katreece Feiertag, Mawien Karaca, Benjamin Fischer, Tanja Heise, Denise Bloch, Tobias Opialla, Tewes Tralau, Carsten Kneuer, Philip Marx-Stoelting

Open access · greenFull text read
In one paragraph

Article in EXCLI journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Katreece FeiertagGerman Federal Institute for Risk Assessment, Department Pesticides Safety, Berlin, Germany.
Mawien KaracaGerman Federal Institute for Risk Assessment, Department Pesticides Safety, Berlin, Germany.
Benjamin FischerGerman Federal Institute for Risk Assessment, Department Pesticides Safety, Berlin, Germany.
Tanja HeiseGerman Federal Institute for Risk Assessment, Department Pesticides Safety, Berlin, Germany.
Denise BlochGerman Federal Institute for Risk Assessment, Department Pesticides Safety, Berlin, Germany.
Tobias OpiallaGerman Federal Institute for Risk Assessment, Department Pesticides Safety, Berlin, Germany.
Tewes TralauGerman Federal Institute for Risk Assessment, Department Pesticides Safety, Berlin, Germany.
Carsten KneuerGerman Federal Institute for Risk Assessment, Department Pesticides Safety, Berlin, Germany.
Philip Marx-StoeltingGerman Federal Institute for Risk Assessment, Department Pesticides Safety, Berlin, Germany.
Federal Institute for Risk Assessment · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant protection products (PPPs) consist of one or more active substances and several co-formulants. Active substances provide the functionality of the PPP and are consequently evaluated according to standard test methods set by legal data requirements before approval, whereas co-formulants' toxicity is not as comprehensively assessed. However, in some cases mixture effects of active substances and co-formulants might result in increased or different forms of toxicity. In a proof-of-concept study we hence built on previously published results of Zahn et al. (2018[38]) on the mixture toxicity of Priori Xtra

Indexed as

co-formulantsCytochrome P450 enzymesliver toxicitymixture effectsplant protection product

Identifiers

PMID36998705
PMCPMC10043434
OpenAlexW4362458638

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read55
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.