ArticleNanoscale advances2023
Sequence-dependent fusion dynamics and physical properties of DNA droplets.
Article in Nanoscale advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Molecular Crowding Stabilizes DNA Coacervate Droplets and Generates Self-Organized Characteristic Patterns.JACS Au · 2026Article
- Semi-Independent Control of Stability and Mobility in DNA Condensates.Chembiochem : a European journal of chemical biology · 2026Article
- Microscopy-based techniques for studying the material properties of biomolecular condensates in the cellular environment.Biophysical reviews · 2025Review
- Engineering Liquid Hierarchical Materials with DNA-Programmed Spherical Nucleic Acids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Remote-controlled mechanical and directional motions of photoswitchable DNA condensates.Nature communications · 2025Article
- Oligolysine Enhances and Inhibits DNA Condensate Formation.ACS omega · 2025Article
- Spatial Control over Reactions via Localized Transcription within Membraneless DNA Nanostar Droplets.Journal of the American Chemical Society · 2024Article
- Co-transcriptional production of programmable RNA condensates and synthetic organelles.Nature nanotechnology · 2024Article
- Temporally controlled multistep division of DNA droplets for dynamic artificial cells.Nature communications · 2024Article
- Fundamental Aspects of Phase-Separated Biomolecular Condensates.Chemical reviews · 2024Review
- A facile DNA coacervate platform for engineering wetting, engulfment, fusion and transient behavior.Communications chemistry · 2024Article
- Pioneering artificial cell-like structures with DNA nanotechnology-based liquid-liquid phase separation.Biophysics and physicobiology · 2024Article
- DNA droplets for intelligent and dynamical artificial cells: from the viewpoint of computation and non-equilibrium systems.Interface focus · 2023Review
- Light-controlled growth of DNA organelles in synthetic cells.Interface focus · 2023Article
- Amphiphiles Formed from Synthetic DNA-Nanomotifs Mimic the Stepwise Dispersal of Transcriptional Clusters in the Cell Nucleus.Nano letters · 2023Article
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Authors and funding
2 authors.
Funding
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Abstract
Liquid-liquid phase separation (LLPS) of biopolymer molecules generates liquid-like droplets. Physical properties such as viscosity and surface tension play important roles in the functions of these droplets. DNA-nanostructure-based LLPS systems provide useful model tools to investigate the influence of molecular design on the physical properties of the droplets, which has so far remained unclear. Herein, we report changes in the physical properties of DNA droplets by sticky end (SE) design in DNA nanostructures. We used a Y-shaped DNA nanostructure (Y-motif) with three SEs as a model structure. Seven different SE designs were used. The experiments were performed at the phase transition temperature where the Y-motifs self-assembled into droplets. We found that the DNA droplets assembled from the Y-motifs with longer SEs exhibited a longer coalescence period. In addition, the Y-motifs with the same length but different sequence SEs showed slight variations in the coalescence period. Our results suggest that the SE length greatly affected the surface tension at the phase transition temperature. We believe that these findings will accelerate our understanding of the relationship between molecular design and the physical properties of droplets formed
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